ArticleScientific reports2023
Combined use of CRP with neutrophil-to-lymphocyte ratio in differentiating between infectious and noninfectious inflammation in hemodialysis patients.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 16 citations in OpenAlex.
- Adjunctive Value of Admission CBC-Derived Inflammation Indices for Catheter-Related Bloodstream Infection in Catheter-Dependent Hemodialysis Patients: A Retrospective Case-Control Study.Diagnostics (Basel, Switzerland) · 2026Article
- The Value of First-Day CRP and NLR in Distinguishing Infectious from Non-Infectious Causes of Loss of Consciousness in the Emergency Department.Open access emergency medicine : OAEM · 2026Article
- Neutrophil to lymphocyte ratio (NLR) and short-term mortality risk in elderly acute medical patients admitted to a University Hospital Emergency Department: comment.Internal and emergency medicine · 2025Article
- Chyloperitoneum in a toddler on peritoneal dialysis.Pediatric nephrology (Berlin, Germany) · 2025Article
- The novel CKD-INF score for distinguishing infectious from non-infectious inflammation in patients with non-dialysis chronic kidney disease.Scientific reports · 2025Article
- Neutrophil-to-Lymphocyte Ratio Differentiates Infections from Sterile Inflammation in First Week of Acute Pancreatitis.Digestive diseases and sciences · 2025Article
- ASSESSING THE PREDICTIVE VALUE OF THE C-REACTIVE PROTEIN AND NEUTROPHIL-TO-LYMPHOCYTE RATIO COMBINED SCORE FOR ORGAN FAILURE IN ACUTE PANCREATITIS.Arquivos de gastroenterologia · 2025Article
- Correlation between neutrophil to lymphocyte ratio and C-reactive protein in diverse disease states in hospitalized patients.Pakistan journal of medical sciences · 2024Article
- Clinical presentations, systemic inflammation response and ANDC scores in hospitalized patients with COVID-19.Scientific reports · 2024Observational
- Effect of Periodontitis on Dry Eye Disease Signs and Symptoms: A Cross-sectional Study.Oral health & preventive dentistry · 2024Article
- Association between serum 25-hydroxyvitamin D level and inflammatory markers in hemodialysis-treated patients.Immunity, inflammation and disease · 2024Article
- The Role of Mannose-Binding Lectin and Inflammatory Markers in Establishing the Course and Prognosis of Community-Acquired Pneumonia in Children.Children (Basel, Switzerland) · 2023Article
- Progress in the application of the neutrophil-to-lymphocyte ratio in dialysis-related complications.Renal failure · 2023Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We tested whether CRP combined with the neutrophil-to-lymphocyte ratio (NLR) optimizes the prediction of infectious inflammation in hemodialysis patients. We conducted a retrospective study of 774 (mean age 71.1 ± 12.8 years, 35% women) hemodialysis patients from our institution, hospitalized between 2007 and 2021 for various reasons, with CRP levels available at admission. Infection was defined according to the International Sepsis Definition Conference criteria. An algorithm for the optimal CRP and NLR cutoff points for predicting infection was developed based on a decision tree analysis in the training cohort (n = 620) and then tested in the validation cohort (n = 154). A CRP level above 40 mg/L (obtained as the cutoff point in predicting infections in the training group, using ROC curve analysis) predicted an infection diagnosis with a sensitivity of 75% and a specificity of 76% with an odds ratio (OR) of 9.37 (95% CI: 5.36-16.39), according to a multivariate logistic regression analysis. Whereas, CRP levels above 23 mg/L together with an NLR above 9.7 predicted an infection diagnosis with a sensitivity of 69% and a specificity of 84% with an OR of 25.59 (95% CI: 9.73-67.31). All these results were reproduced in the validation set. Combined use of CRP with NLR may lower the CRP cutoff point in distinguishing between infectious and noninfectious inflammation in hemodialysis patients.
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