ArticleThe Journal of infectious diseases2023
Bronchiolitis, Regardless of Its Etiology and Severity, Is Associated With Increased Risk of Asthma: A Population-Based Study.
Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Prevalence of common respiratory viruses of infants with respiratory tract infections in European countries in the past decade: a systematic review and meta-analysis comparing between the pre-COVID-19, pandemic, and post-COVID-19 periods.European journal of pediatrics · 2026Pooled it
- Association between age of respiratory syncytial virus infection hospitalization and childhood asthma: A systematic review.PloS one · 2024Pooled it
- Rhinovirus Species in Acute Respiratory Tract Infections and the Risk of Asthma in Children.Pediatric pulmonology · 2026Article
- Nirsevimab Implementation and Primary Management of Lower Respiratory Tract Infections in Infants in Spain: A Quasi-Experimental Study.Indian pediatrics · 2026Article
- Impact of regional heterogeneity of RSV infection prophylaxis on bronchiolitis in Italy.Italian journal of pediatrics · 2026Observational
- Longitudinal Study of Subsequent Wheezing/Asthma Risk Among Children Hospitalized for Acute Respiratory Infections - Yichang City, Hubei Province, China, 2017-2024.China CDC weekly · 2026Article
- Nasopharyngeal Microbiome-Epigenome-Wide Association Analysis in Infants With Severe Bronchiolitis.Allergy · 2026Article
- Caregiver awareness of pediatric respiratory red-flag signs and emergency activation intentions: a province-wide cross-sectional study in China.Frontiers in medicine · 2026Article
- Machine learning reveals immune heterogeneity in recovery-phase samples of pediatric wheezing.Frontiers in pediatrics · 2026Article
- Non-type 2 airway inflammation in severe asthma: from bench to bedside.Frontiers in immunology · 2026Review
- Recurrent wheezing as a mediator between early-life exposures and childhood asthma: a mediation analysis in an Italian primary care paediatric cohort.BMJ public health · 2026Article
- Association between early-life respiratory syncytial virus infection and the risk of asthma: a meta-analysis.Journal of thoracic disease · 2025Article
- Long Term Sequelae of Mild RSV Infections in Healthy Children Aged 0-3 Years in the Primary Care Setting-A Prospective Two Year Follow Up Observational Study.Journal of medical virology · 2025Observational
- Risk factors for recurrent wheezing after infant bronchiolitis: a 6-year single-centre follow up study in China.Frontiers in pediatrics · 2025Article
- The changing epidemiology of paediatric childhood asthma and allergy in different regions of the world.Frontiers in allergy · 2025Review
- Integrated nasopharyngeal airway metagenome and asthma genetic risk endotyping of severe bronchiolitis in infancy and risk of childhood asthma.The European respiratory journal · 2024Article
- Association between nasopharyngeal airway lipidome signatures of infants with severe bronchiolitis and risk of recurrent wheeze: A prospective multicenter cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Association of Wheezing Requiring Hospitalization Before 2 Years of Age With Autoimmune Diseases During Childhood: A 15-Year Follow-up Study From Birth.Allergy, asthma & immunology research · 2024Article
- Factors Predicting Secondary Respiratory Morbidity Following Early-Life Respiratory Syncytial Virus Infections: Population-Based Cohort Study.Open forum infectious diseases · 2023Article
- From small to big, using microRNA profiling to investigate infant origins of childhood asthma.The European respiratory journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An association exists between severe respiratory syncytial virus (RSV)-bronchiolitis and a subsequent increased risk of recurrent wheezing (RW) and asthma. However, a causal relationship remains unproven. Using a retrospective population-based cohort study (339 814 children), bronchiolitis during the first 2 years of life (regardless of etiology and severity) was associated with at least a 3-fold increased risk of RW/asthma at 2-4 years and an increased prevalence of asthma at ≥5 years of age. The risk was similar in children with mild bronchiolitis as in those with hospitalized RSV-bronchiolitis and was higher in children with hospitalized non-RSV-bronchiolitis. The rate of RW/asthma was higher when bronchiolitis occurred after the first 6 months of life. Our results seem to support the hypothesis of a shared predisposition to bronchiolitis (irrespective of etiology) and RW/asthma. However, 60% of hospitalized bronchiolitis cases in our setting are due to RSV, which should be paramount in decision-making on imminent RSV prevention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.