Evidence map›Paper›PMID 37015885›Full record

ArticleMolecular pain

Genetic evidence of the function of Phox2a-expressing anterolateral system neurons in the transmission of chronic pain.

Xinying Zhang, Magali Millecamps, Artur Kania

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xinying ZhangNeural Circuit Development Laboaratory, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada.ORCID 0000-0001-7668-8110
Magali MillecampsABC-platform (Animal Behavioral Characterization), McGill University, Montreal, QC, Canada.
Artur KaniaNeural Circuit Development Laboaratory, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada.ORCID 0000-0002-5209-2520
Montreal Clinical Research Institute · CAMcGill University · CA

Funding

CIHR
6 · The paper itself

Abstract

The development of the chronic neuropathic pain state often originates at the level of peripheral sensory neurons, whose abnormal function elicits central sensitization and maladaptive plasticity in the nociceptive circuits of the spinal dorsal horn. These changes eventually reach supraspinal areas bringing about cognitive and affective co-morbidities of chronic pain such as anxiety and depression. This transmission presumably relies on the function of spinal projection neurons at the origin of the anterolateral system (AS). However, the identity of these neurons and the extent of their functional contribution remain unknown. Here, we asked these questions in the context of the mouse AS neurons that require the transcription factor Phox2a for their normal target connectivity and function in transmitting acute nociceptive information to the brain. To this end, we examined the effects of a spinal cord-specific loss of Phox2a (Phox2a

Indexed as

Chronic PainNeuralgiaAnimalsHomeodomain ProteinsHyperalgesiaMiceNeuronsSpinal Cord Dorsal HornHomeodomain ProteinsPhox2a protein, mouseallodyniaanterolateral systemanxiodepressive- like behavioursChronic pain modelhypersensitivitynocifensive behaviourPhox2aspared nerve injuryspinal cordspinal projection neurons

Identifiers

PMID37015885
PMCPMC10291149
OpenAlexW4362594759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.