Evidence map›Paper›PMID 37014687›Full record

ReviewArhiv za higijenu rada i toksikologiju2023

Genotoxic and genoprotective effects of 1,4-dihydropyridine derivatives: a brief review.

Elina Leonova, Nadezhda Ryabokon, Evita Rostoka, Vitalijs Borisovs, Astrida Velena, Egils Bisenieks, Gunars Duburs, Maija Dzintare, Roza Goncharova, Nikolajs Sjakste

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Arhiv za higijenu rada i toksikologiju, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Elina LeonovaUniversity of Latvia Faculty of Medicine, Medical Biochemistry Department, Riga, Latvia.
Nadezhda RyabokonNational Academy of Sciences of Belarus, Institute of Genetics and Cytology, Minsk, Belarus.
Evita RostokaUniversity of Latvia Faculty of Medicine, Medical Biochemistry Department, Riga, Latvia.
Vitalijs BorisovsUniversity of Latvia Faculty of Medicine, Medical Biochemistry Department, Riga, Latvia.
Astrida VelenaLatvian Institute of Organic Synthesis, Riga, Latvia.
Egils BisenieksLatvian Institute of Organic Synthesis, Riga, Latvia.
Gunars DubursLatvian Institute of Organic Synthesis, Riga, Latvia.
Maija DzintareLatvian Academy of Sport Education, Department of Anatomy, Physiology, Biochemistry, Biomechanics, Hygiene and Informatics, Riga, Latvia.
Roza GoncharovaNational Academy of Sciences of Belarus, Institute of Genetics and Cytology, Minsk, Belarus.
Nikolajs SjaksteUniversity of Latvia Faculty of Medicine, Medical Biochemistry Department, Riga, Latvia.
University of Latvia · LVLatvijas Organiskās Sintēzes Institūts · LVInstitute of Genetics and Cytology of the National Academy of Sciences of Belarus · BYLatvian Academy of Sport Education · LV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review summarises current knowledge about the genotoxic and genoprotective effects of 1,4-dihydropyridines (DHP) with the main focus on the water-soluble 1,4-DHPs. Most of these water-soluble compounds manifest very low calcium channel blocking activity, which is considered "unusual" for 1,4-DHPs. Glutapyrone, diludine, and AV-153 decrease spontaneous mutagenesis and frequency of mutations induced by chemical mutagens. AV-153, glutapyrone, and carbatones protect DNA against the damage produced by hydrogen peroxide, radiation, and peroxynitrite. The ability of these molecules to bind to the DNA may not be the only mechanism of DNA protection, as other mechanisms such as radical scavenging or binding to other genotoxic compounds may take place and enhance DNA repair. These uncertainties and reports of high 1,4-DHP concentrations damaging the DNA call for further

Indexed as

Calcium Channel BlockersDNA DamageDihydropyridinesDNA Repair1,4-dihydropyridineCalcium Channel BlockersDihydropyridines1,4-DHPAV-153carbatonesdiludindiludineDNA bindingglutapironglutapyronekarbatonivezanje za DNA

Identifiers

PMID37014687
PMCPMC10231893
OpenAlexW4362523183

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.