ArticleEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2023
Remineralization potential of phosphorylated chitosan and silver diamine fluoride in comparison to sodium fluoride varnish: invitro study.
Article in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Transforming Pediatric Dentistry with Chitosan Gel: Current Evidence and Emerging Trends-A Scoping Review.Materials (Basel, Switzerland) · 2026Review
- Comparison of the Microhardness of Primary Dentin With Artificially Induced Caries Following the Application of Sodium Fluoride Varnish With the Intensive Technique Versus Fluoride Therapy With Silver Diamine Fluoride.International journal of dentistry · 2026Article
- The differences of enamel hardness post application of silver diamine fluoride and fluoride varnish on demineralized tooth surface (in vitro).Scientific reports · 2025Article
- The Effect of Silver Diamine Fluoride Combined with Potassium Iodide and Sodium Fluoride on the Remineralisation of Hydroxyapatite.Oral health & preventive dentistry · 2025Article
- Silver nanoparticles versus chitosan nanoparticles effects on demineralized enamel.BMC oral health · 2024Article
- Effect of silver diamine fluoride activation on bond strength to root dentin.BMC oral health · 2023Article
- Evaluation of the biological, physical, mechanical and chemical properties of orthodontic primer modified by nano-chitosan loaded with bioactive materials.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to evaluate and compare the remineralization potential of phosphorylated chitosan nanoparticles (Pchi) and silver diamine fluoride (SDF) compared to sodium fluoride varnish (NaF) on microhardness of artificial carious lesions in a biomimetic minimally invasive approach that is being regarded as the future of preventive dentistry.
methodsThe sample size included 40 intact extracted maxillary anterior human teeth. Baseline microhardness was recorded using Vickers hardness test and energy-dispersive X-ray spectroscopy (EDX). Artificial caries-like lesions were created on the exposed enamel by suspending all teeth in demineralizing solution for 10 days in a temperature of 37 °C and then the hardness and EDX were remeasured. Samples were then divided into four main groups: Group A (positive control group) n = 10, treated with NaF, Group B n = 10, treated with SDF, Group C n = 10, treated with Pchi and Group D (negative control group) n = 10 that received no treatment. After treatment, samples were incubated in artificial saliva solution at 37 °C in for 10 days and then reassessed. Data were then recorded, tabulated, and statistically analyzed using Kruskal-Wallis test and Wilcoxon signed test. Scanning electron microscope (SEM) was used to analyze the morphological changes of enamel surface after treatment.
resultsGroups B and C showed the highest calcium (Ca) and phosphate (P) content as well as hardness values, while group B had the highest percentage of fluoride. SEM revealed a smooth layer of mineral formed on the surface of enamel for both groups.
conclusionPchi and SDF showed the highest increase in enamel microhardness and remineralization potential. CLINICAL RELEVANCE: The minimally invasive approach for remineralization could be enhanced using SDF and Pchi.
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