Evidence map›Paper›PMID 37014574›Full record

ArticleSpine deformity2023

Inter-screw index as a novel diagnostic indicator of tether breakage.

Sandra H T Wan, Ogulcan Guldeniz, Matthew H Y Yeung, Jason P Y Cheung, Kenny Y H Kwan, Kenneth M C Cheung

Abstract read
In one paragraph

Article in Spine deformity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Answer to the Letter to the Editor of A. Abudayeh, et al. concerning "Does screw alignment affect tether breakage in vertebral body tethering?" by S. Wan, et al. (Eur Spine J [2025]; doi: 10.1007/s00586-025-09299-6).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
  5. Letter to the Editor concerning "Does screw alignment affect tether breakage in vertebral body tethering?" by S. Wan, et al. (Eur Spine J [2025]; doi: 10.1007/s00586-025-09299-6).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
  6. Article
  7. Does screw alignment affect tether breakage in vertebral body tethering?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
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  12. A multibody simulation of the spine for objectification of biomechanical quantities after VBT: a proof of concept and description of baseline data.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandra H T Wan *Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-7974-5421
Ogulcan Guldeniz *Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-2132-8342
Matthew H Y YeungDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-5746-2535
Jason P Y CheungDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-7052-0875
Kenny Y H KwanDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-4034-8525
Kenneth M C CheungDepartment of Orthopaedic Surgery, HKU-Shenzhen Hospital, Shenzhen, China. cheungmc@hku.hk.ORCID http://orcid.org/0000-0001-8304-0419

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTether breakage is the most common complication of Vertebral Body Tethering (VBT) occurring in up to 52% of Adolescent Idiopathic Scoliosis (AIS) patients and risks continued progression and revision. Radiographical diagnosis of tether breakage is commonly defined by a 5° increase in inter-screw angle and associates breakage with loss of correction. However, the sensitivity of this method was 56% only, suggesting that tethers can break without an increase in angulation, which was supported by other studies. To our knowledge, current literature lacks a method merely focusing on the diagnosis of tether breakage radiographically that does not associate the breakages with loss of correction.

methodsThis was a retrospective review of prospectively collected data of AIS patients who underwent VBT. The "inter-screw index" is defined as the percentage increase in inter-screw distance since post-op, with ≥ 13% increase defined as tether breakage as suggested by our mechanical tests. CTs were reviewed to identify the breakages and compared with inter-screw angle and inter-screw index.

results94 segments from 13 CTs were reviewed, and 15 tether breakages were identified. Use of inter-screw index correctly identified 14 breakages (93%), whereas ≥ 5° increase in inter-screw angle only identified 12 breakages (80%).

conclusionUse of inter-screw index is proven to be more sensitive than inter-screw angle in identifying tether breakages. Therefore, we propose the use of inter-screw index to diagnose tether breakages radiographically. Tether breakages were not necessarily accompanied by a loss of segmental correction leading to an increase in inter-screw angle, especially after skeletal maturity. LEVEL OF EVIDENCE: Level 3.

Indexed as

KyphosisScoliosisAdolescentBone ScrewsHumansRadiographyThoracic VertebraeAdolescent idiopathic scoliosisTether breakageVertebral body tethering

Identifiers

PMID37014574
PMCPMC10261206

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.