Evidence map›Paper›PMID 37014443›Full record

SynthesisEuropean journal of pediatrics2023

To feed or not to feed during therapeutic hypothermia in asphyxiated neonates: a systematic review and meta-analysis.

Jogender Kumar, Rajendra Prasad Anne, Jitendra Meena, Venkataseshan Sundaram, Sourabh Dutta, Praveen Kumar

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06447155 (The Impact of Continuous Versus Bolus Feeding in Neonates With Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06447155 naunknown statusnot on this mapstarted 2024, after this paper: background citation

The Impact of Continuous Versus Bolus Feeding in Neonates With Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia

TypeinterventionalSponsorIstanbul Training and Research HospitalRan2024 to 2026Enrolled60ConditionsHypoxic Ischemic Encephalopathy of Newborn, Feeding PatternsArmsBolus feeding, Continuous feeding, Placebo
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jogender KumarDepartment of Pediatrics, Neonatal Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India.ORCID http://orcid.org/0000-0002-0464-9689
Rajendra Prasad AnneDepartment of Pediatrics, All India Institute of Medical Sciences, Bibi Nagar, Telangana, India.
Jitendra MeenaDepartment of Pediatrics, All India Institute of Medical Science, Jodhpur, Rajasthan, India.
Venkataseshan SundaramDepartment of Pediatrics, Neonatal Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Sourabh DuttaDepartment of Pediatrics, Neonatal Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Praveen KumarDepartment of Pediatrics, Neonatal Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India. drpkumarpgi@gmail.com.ORCID http://orcid.org/0000-0003-4742-8787
Post Graduate Institute of Medical Education and Research · INAll India Institute of Medical Sciences · INAll India Institute of Medical Sciences Jodhpur · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The practice of withholding feed during therapeutic hypothermia (TH) in neonates with hypoxemic ischemic encephalopathy (HIE) is based on conventions rather than evidence. Recent studies suggest that enteral feeding might be safe during TH. We systematically compared the benefits and harms of enteral feeding in infants undergoing TH for HIE. We searched electronic databases and trial registries (MEDLINE, CINAHL, Embase, Web of Science, and CENTRAL) until December 15, 2022, for studies comparing enteral feeding and non-feeding strategies. We performed a random-effects meta-analysis using RevMan 5.4 software. The primary outcome was the incidence of stage II/III necrotizing enterocolitis (NEC). Other outcomes included the incidence of any stage NEC, mortality, sepsis, feed intolerance, time to full enteral feeds, and hospital stay. Six studies ((two randomized controlled trials (RCTs) and four nonrandomized studies of intervention (NRSIs)) enrolling 3693 participants were included. The overall incidence of stage II/III NEC was very low (0.6%). There was no significant difference in the incidence of stage II/III NEC in RCTs (2 trials, 192 participants; RR, 1.20; 95% CI: 0.53 to 2.71, I

Indexed as

Enterocolitis, NecrotizingHypothermia, InducedHypoxia-Ischemia, BrainInfant, Newborn, DiseasesInfant, Premature, DiseasesSepsisStrokeHumansInfant, NewbornInfant, PrematureRandomized Controlled Trials as TopicCoolingFeed intoleranceInfantNecrotizing enterocolitisPerinatal asphyxiaTherapeutic hypothermia

Identifiers

PMID37014443
OpenAlexW4362521909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.