ArticleObesity (Silver Spring, Md.)2023
Causal effect of adiposity on the risk of 19 gastrointestinal diseases: a Mendelian randomization study.
Article in Obesity (Silver Spring, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Environmental Protective and Risk Factors for Gastric Cancer: An Umbrella Review and Reanalysis of Meta-Analyses.Journal of gastric cancer · 2025Pooled it
- Genetic estimation of causalities between educational attainment with common digestive tract diseases and the mediating pathways.BMC gastroenterology · 2024Pooled it
- Unraveling the causal web of 4 adiposity indices and 92 multi-system outcomes: A body-wide Mendelian randomization study.Medicine · 2026Article
- Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities.Cell metabolism · 2026Article
- Polyunsaturated Fatty Acids and Skin Cancer: Two-Sample Mendelian Randomization Study.Annals of dermatology · 2025Article
- Gene-Diet interaction between FTO rs9939609 and fiber intake in relation to GERD susceptibility.Molecular biology reports · 2025Article
- Prospects of Mendelian randomization in hepatology: a comprehensive literature review with practice guidance.Clinical and molecular hepatology · 2025Review
- Sex-specific association of visceral and abdominal subcutaneous adipose tissue with gastroesophageal reflux disease: a large-scale perspective cohort study.BMC gastroenterology · 2025Article
- Genetically proxied risk and protective factors for pancreatic cancer: a systematic review and meta-analysis of Mendelian randomization studies.Journal of gastrointestinal oncology · 2025Article
- Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank.IBRO neuroscience reports · 2025Article
- Comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigs.Scientific reports · 2025Article
- Global burden of gallbladder and biliary diseases (1990-2021) with healthcare workforce analysis and projections to 2035.BMC gastroenterology · 2025Article
- Maternal Smoking Around Birth Is a Risk Factor for Gastrointestinal Diseases in Offspring: A Mendelian Randomization Study.Digestive diseases and sciences · 2025Article
- Long-term trends in the burden of cancer attributable to high body mass index in China from 1990 to 2021.Frontiers in nutrition · 2025Article
- Association of life's essential 8 with mortalities in patients with alcohol-related liver disease.BMC gastroenterology · 2024Article
- Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities.Cell metabolism · 2024Article
- Relationship between obesity indexes and triglyceride glucose index with gastrointestinal cancer among the US population.Preventive medicine reports · 2024Article
- Mendelian randomisation analysis for intestinal disease: achievement and future.eGastroenterology · 2024Review
- The role of metabolic factors in the association between obesity and cholelithiasis: A two-step, two-sample multivariable mendelian randomization study.Clinics (Sao Paulo, Brazil) · 2024Article
- The causal relationship between diet habits and cholelithiasis: a comprehensive Mendelian randomization (MR) study.Frontiers in nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveAlthough the association between adiposity and gastrointestinal (GI) diseases has been explored, the causal effects of adiposity on GI diseases are largely unknown.
methodsMendelian randomization was conducted using single-nucleotide polymorphisms associated with BMI and waist circumference (WC) as instrumental variables, and the causal associations of BMI or WC with GI conditions were estimated among >400,000 UK Biobank participants, >170,000 Finnish-descent participants, and numerous consortia participants of predominantly European ancestry.
resultsGenetically predicted BMI was robustly associated with increased risk of nonalcoholic fatty liver disease (NAFLD), cholecystitis, cholelithiasis, and primary biliary cholangitis. For the diseases, the odds ratio per 1-SD increase in genetically predicted BMI (4.77 kg/m
conclusionsHigh genetically predicted adiposity was causally associated with an increased risk of GI abnormalities, particularly of hepatobiliary organs (liver, biliary tract, and gallbladder) that are functionally related to fat metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.