Evidence map›Paper›PMID 37014052›Full record

ArticleeLife2023

GABA

Daniel C Cook, Timothy A Ryan

Abstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel C CookDepartment of Anesthesiology, Weill Cornell Medical College, New York, United States.ORCID 0000-0003-0714-4050
Timothy A RyanDepartment of Anesthesiology, Weill Cornell Medical College, New York, United States.ORCID 0000-0003-2533-9548

Funding

Physiology of Single Synaptic CNS TerminalsR01NS036942 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Timothy Aidan Ryan · 1998 to 2026
$6.8M
Physiology of Single Synaptic CNS TerminalsR37NS036942 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI RYAN, TIMOTHY AIDAN · 2016 to 2022
$3.5M
Metabolic Vulnerability of Synapses in Neurodegenerative DiseaseR01NS117139 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI RYAN, TIMOTHY AIDAN · 2020 to 2024
$2.0M
Metabolic impact of Intralipid on synaptic function as a mechanism of resuscitation in local anesthetic systemic toxicityK08GM148935 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Daniel Charles Cook · 2023 to 2026
$780k
NIGMS NIH HHS K08 GM148935NINDS NIH HHS R01 NS036942NINDS NIH HHS R01 NS117139NINDS NIH HHS R37 NS036942
6 · The paper itself

Abstract

Control of neurotransmission efficacy is central to theories of how the brain computes and stores information. Presynaptic G-protein coupled receptors (GPCRs) are critical in this problem as they locally influence synaptic strength and can operate on a wide range of time scales. Among the mechanisms by which GPCRs impact neurotransmission is by inhibiting voltage-gated calcium (Ca

Indexed as

Presynaptic TerminalsSynapsesAction PotentialsCalciumgamma-Aminobutyric AcidSynaptic TransmissionCalciumgamma-Aminobutyric Acidcalcium channelexocytosisneuroscienceratsynapse

Identifiers

PMID37014052
PMCPMC10115440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.