Evidence map›Paper›PMID 37014051›Full record

ArticleeLife2023

Structural and regulatory insights into the glideosome-associated connector from

Amit Kumar, Oscar Vadas, Nicolas Dos Santos Pacheco, Xu Zhang, Kin Chao, Nicolas Darvill, Helena Ø Rasmussen, Yingqi Xu, Gloria Meng-Hsuan Lin, Fisentzos A Stylianou and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Amit KumarDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Oscar VadasDepartment of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0003-3511-6479
Nicolas Dos Santos PachecoDepartment of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0003-1959-194X
Xu ZhangDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Kin ChaoDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Nicolas DarvillDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Helena Ø RasmussenInterdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-8384-656X
Yingqi XuDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Gloria Meng-Hsuan LinDepartment of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Fisentzos A StylianouDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Jan Skov PedersenInterdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Aarhus, Denmark.
Sarah L RouseDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Marc L MorganDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Dominique Soldati-FavreDepartment of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0003-4156-2109
Stephen MatthewsDepartment of Life Sciences, Imperial College London, London, United Kingdom.ORCID 0000-0003-0676-0927
Imperial College London · GBUniversity of Geneva · CHAarhus University · DK

Funding

Biotechnology and Biological Sciences Research Council BB/D524840/1Medical Research Council MR/T017961/1Wellcome Trust
6 · The paper itself

Abstract

The phylum of Apicomplexa groups intracellular parasites that employ substrate-dependent gliding motility to invade host cells, egress from the infected cells, and cross biological barriers. The glideosome-associated connector (GAC) is a conserved protein essential to this process. GAC facilitates the association of actin filaments with surface transmembrane adhesins and the efficient transmission of the force generated by myosin translocation of actin to the cell surface substrate. Here, we present the crystal structure of

Indexed as

ToxoplasmaActin CytoskeletonActinsCell MembraneMyosinsProtozoan ProteinsActinsMyosinsProtozoan Proteinsapicomplexaconnector proteinglideosomehumaninfectious diseaseinvasionmicrobiologymolecular biophysicsNMRP. falciparumprotein crystallographystructural biology

Identifiers

PMID37014051
PMCPMC10125020
OpenAlexW4362520906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.