ArticleTrials2023
Quantifying the impact of the COVID-19 pandemic on clinical trial screening rates over time in 37 countries.
Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Videoconferencing with the Hospitalized Premature Infant while Expressing Milk: A Randomized Crossover Trial.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2026Trial
- Trial
- A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain.Journal of pain research · 2025Trial
- Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial.Alzheimer's research & therapy · 2024Trial
- Oncology drug development in the UK: analysis of the past 25 years and focus on the 2026 reboot of the clinical trial regulatory framework.British journal of cancer · 2026Article
- The evolving landscape of inflammation-related clinical trials: a 25-year registry-based network analysis from a clinical pharmacology perspective.Translational and clinical pharmacology · 2026Article
- Educators, Not Influencers: Health Content Creator Perspectives on Research Recruitment Collaboration.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Assessment of tumor mutation burden based on whole-exome sequencing of extracellular vesicle-derived DNA from bronchoalveolar lavage fluid in advanced non-small cell lung cancer treated with pembrolizumab: a prospective, multicenter, observational study.Translational lung cancer research · 2026Article
- Direct-to-Participant Enrollment in a Virtual Trial: Lessons Learned From the Heartline Study.JACC. Advances · 2026Article
- A comparison of conservative versus surgical treatment in patients with foot drop due to peroneal nerve entrapment: results of a prematurely terminated randomized controlled trial.Brain & spine · 2026Article
- Letter to the Editor in response to the article 'Retrospective analysis of influences of sacubitril/valsartan in patients with diabetes with poorly controlled blood pressure in Japan'.Journal of diabetes investigation · 2025Article
- Improving Patient Engagement in Phase 2 Clinical Trials With a Trial-Specific Patient Decision Aid: Development and Usability Study.Journal of medical Internet research · 2025Article
- Feasibility of Multi-Institutional Data Collection for Medication Prior Authorization in Pediatric Oncology.JCO oncology practice · 2025Article
- Factors that influence clinical trial participation for oncology patients in Australia: a scoping review.BMJ open · 2025Article
- Wearable-Enhanced mHealth Intervention to Promote Physical Activity in Manual Wheelchair Users: Single-Group Pre-Post Feasibility Study.JMIR rehabilitation and assistive technologies · 2025Article
- Patient-Reported Factors Influencing Clinical Trial Participation: An In-depth Analysis of Patients With Lupus and Rheumatoid Arthritis.ACR open rheumatology · 2025Review
- Augmenting Insufficiently Accruing Oncology Clinical Trials Using Generative Models: Validation Study.Journal of medical Internet research · 2025Article
- Article
- Engagement, efficacy, and experiences of psychotherapy for perinatal populations with depression and anxiety during the COVID-19 pandemic.Frontiers in psychiatry · 2025Article
- BMScope: A scoping review to chart the evolving clinical study landscape in brain and leptomeningeal metastasis.Neuro-oncology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic has had an unprecedented and disruptive impact on people's health and lives worldwide. In addition to burdening people's health in the short-term in the form of infection, illness, and mortality, there has been an enormous negative impact on clinical research. Clinical trials experienced challenges in ensuring patient safety and enrolling new patients throughout the pandemic. Here, we investigate and quantify the negative impact that the COVID-19 pandemic has industry-sponsored clinical trials, both in the USA and worldwide. We find a negative correlation between the severity of the COVID-19 pandemic and clinical trial screening rate, with the relationship being strongest during the first three months of the pandemic compared to the entire duration of the pandemic. This negative statistical relationship holds across therapeutic areas, across states in the USA despite the heterogeneity of responses at the state-level, and across countries. This work has significant implications for the management of clinical trials worldwide in response to the fluctuating severity of COVID-19 moving forward and for future pandemics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.