ArticleWorld journal of surgical oncology2023
Preoperative anemia and long-term survival in patients undergoing colorectal cancer surgery: a retrospective cohort study.
Article in World journal of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Association between peri-operative red blood cell transfusion and cancer recurrence in patients undergoing major cancer surgery: an umbrella review.Anaesthesia · 2025Pooled it
- Preoperative Laboratory, Imaging, and Risk Assessment Before Elective Colorectal Cancer Resection: What the Clinician Must Remember.Journal of clinical medicine · 2026Review
- Association between preoperative HALP score and anastomotic leakage following colorectal cancer resection: A retrospective cohort study.Turkish journal of surgery · 2026Article
- Preoperative anemia, transfusions and survival in colorectal cancer surgery-A retrospective study.Wiener klinische Wochenschrift · 2026Article
- Impact of Preoperative Anemia on Short-Term Outcomes After Colorectal Cancer Surgery: How the Choice of Diagnostic Criteria Leads to Conflicting Findings.Clinical Medicine Insights. Oncology · 2026Article
- A study on risk prediction of decline in self-care ability one month after discharge in postoperative colorectal cancer patients based on routine clinical indicators.Frontiers in surgery · 2026Article
- The correlation between clinical and pathological features of renal cancer patients with survival after surgical intervention.Caspian journal of internal medicine · 2026Article
- Impact of preoperative anemia on postoperative rate of severe complications and short-term clinical outcomes after retroperitoneal tumor resection.BMC anesthesiology · 2025Article
- Associations of early postoperative anemia with mortality and ICU outcomes in nonagenarians and centenarians undergoing colorectal cancer surgery: a binational multicenter propensity matching study.World journal of surgical oncology · 2025Article
- Optimizing Preoperative Anemia in Non-Metastatic Colorectal Cancer: A Systematic Review on Surgical Recovery and Outcomes.Cancers · 2025Review
- Intravenous Iron for Perioperative Anaemia in Colorectal Cancer Surgery: A Nested Cohort Analysis.Cancers · 2025Article
- Article
- An overview of the current evidences on the role of iron in colorectal cancer: a review.Frontiers in oncology · 2025Review
- Prediction model of gastrointestinal tumor malignancy based on coagulation indicators such as TEG and neural networks.Frontiers in immunology · 2025Article
- Article
- Postoperative Intravenous Iron Infusion in Anemic Colorectal Cancer Patients: An Observational Study.Biomedicines · 2024Article
- The Value of Systemic Inflammatory Indices for Predicting Early Postoperative Complications in Colorectal Cancer.Medicina (Kaunas, Lithuania) · 2024Article
- YTHDF1's grip on CRC vasculature: insights into LINC01106 and miR-449b-5p-VEGFA axis.Cancer cell international · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe impact of preoperative anemia on a survival outcome and the importance of correcting preoperative anemia in patients with colorectal cancer (CRC) remain controversial. This study aimed to explore how preoperative anemia affects the long-term survival of patients undergoing colorectal cancer surgery.
methodsThis was a retrospective cohort study in which adult patients underwent surgical resection for colorectal cancer between January 1, 2008, and December 31, 2014, at a large tertiary cancer center. A total of 7436 patients were enrolled in this study. Anemia was defined according to the diagnostic criteria of China (hemoglobin level < 110 g/L for women and < 120 g/L for men). The median follow-up time was 120.5 months (10.0 years). Inverse probability of treatment weighting (IPTW) using the propensity score was used to reduce selection bias. Overall survival (OS) and disease-free survival (DFS) were compared between patients with and without preoperative anemia using the Kaplan-Meier estimator and the weighted log-rank test based on IPTW. Univariate and multivariate Cox proportional hazards models were used to assess factors associated with OS and DFS. Multivariable Cox regression was also used to assess red blood cell (RBC) transfusion associations between preoperative anemia and outcomes.
resultsAfter IPTW adjustment, clinical profiles were similar, except that tumor location and TNM stage remained imbalanced between the preoperative anemia and preoperative non-anemia groups (p < 0.001). IPTW analysis showed that the 5-year OS rate (71.3 vs. 78.6%, p < 0.001) and the 5-year DFS rate (63.9 vs. 70.9%, p < 0.001) were significantly lower in the preoperative anemia group. Multivariate analysis showed that preoperative anemia was associated with poorer OS and DFS, while RBC transfusion may improve OS (hazard ratio [HR] 0.54, p = 0.054) and DFS (HR 0.50, p = 0.020) in CRC patients with preoperative anemia.
conclusionsPreoperative anemia is an independent risk factor for survival in patients undergoing colorectal surgery. Strategies to reduce preoperative anemia in patients with CRC should be considered.
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