ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
Metabolome-Based Genome-Wide Association Study of Duck Meat Leads to Novel Genetic and Biochemical Insights.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Utilization of nanosensors and nanomaterials to revolutionize the food industry: boosting product safety, quality, and sustainability.RSC advances · 2026Review
- Integration of whole genome resequencing and transcriptomics reveals key candidate genes and pathway for fatty acid and amino acid compositions among duck breeds.Poultry science · 2026Article
- Carbohydrate metabolism and phosphorylation cascades regulate flavor formation in chicken meat.Food chemistry. Molecular sciences · 2026Article
- Metabolite-based genome-wide association analysis reveals genetic loci and candidate genes affecting breast muscle metabolites in Sansui ducks.Poultry science · 2026Article
- Meat quality and metabolism alterations in broiler driven by selective breeding and their associations with gut microbiota.Food chemistry: X · 2026Article
- Pan-3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Integrated miRNAs, Transcriptome, and Metabolome Uncover Underlying Mechanisms for Breast Muscle Metabolic Regulation in Liancheng White and Cherry Valley Ducks.Animals : an open access journal from MDPI · 2026Article
- Comprehensive Genetic Map of Muscle Lipidome Reveals Novel Insights Into Flavor Variation in Ruminant Meat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A New Family-Based Approach for Detecting Allele-Specific Expression and for Mapping Possible eQTLs.Animals : an open access journal from MDPI · 2025Article
- Effects of supplementary and restricted feeding on meat flavor, lipid metabolism and muscle protein metabolism of Hu sheep.Food chemistry: X · 2025Article
- Article
- Merging metabolomics and genomics provides a catalog of genetic factors that influence molecular phenotypes in pigs linking relevant metabolic pathways.Genetics, selection, evolution : GSE · 2025Article
- Effects of Different Levels ofAntioxidants (Basel, Switzerland) · 2025Article
- A high-quality assembly revealing the PMEL gene for the unique plumage phenotype in Liancheng ducks.GigaScience · 2025Article
- Genome-wide association analysis reveals the genetic basis of ionomic variation in duck breast muscle.Journal of animal science · 2025Article
- Identification of Candidate Genes for Sebum Deposition in Pekin Ducks Using Genome-Wide Association Studies.Genes · 2024Article
- Application of GWAS and mGWAS in Livestock and Poultry Breeding.Animals : an open access journal from MDPI · 2024Review
- Genome-wide association study provided insights into the polled phenotype and polled intersex syndrome (PIS) in goats.BMC genomics · 2024Article
- Tryptophan Promotes the Production of Xanthophyll Compounds in Yellow Abdominal Fat throughAnimals : an open access journal from MDPI · 2024Article
- Analysis of genomic copy number variations through whole-genome scan in Yunling cattle.Frontiers in veterinary science · 2024Article
Corrections and comments
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Authors and funding
20 authors at 1 institution in 1 country.
Funding
Abstract
Meat is among the most consumed foods worldwide and has a unique flavor and high nutrient density in the human diet. However, the genetic and biochemical bases of meat nutrition and flavor are poorly understood. Here, 3431 metabolites and 702 volatiles in 423 skeletal muscle samples are profiled from a gradient consanguinity segregating population generated by Pekin duck × Liancheng duck crosses using metabolomic approaches. The authors identified 2862 metabolome-based genome-wide association studies (mGWAS) signals and 48 candidate genes potentially modulating metabolite and volatile levels, 79.2% of which are regulated by cis-regulatory elements. The level of plasmalogen is significantly associated with TMEM189 encoding plasmanylethanolamine desaturase 1. The levels of 2-pyrrolidone and glycerophospholipids are regulated by the gene expression of AOX1 and ACBD5, which further affects the levels of volatiles, 2-pyrrolidone and decanal, respectively. Genetic variations in GADL1 and CARNMT2 determine the levels of 49 metabolites including L-carnosine and anserine. This study provides novel insights into the genetic and biochemical basis of skeletal muscle metabolism and constitutes a valuable resource for the precise improvement of meat nutrition and flavor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.