A structure activity relationship study of 3,4'-dimethoxyflavone for ArlRS inhibition in
Alexander W Weig, Patrick M O'Conner, Jakub M Kwiecinski, Orry M Marciano, Angelica Nunag, Andrew T Gutierrez, Roberta J Melander, Alexander R Horswill, Christian Melander
Article in Organic & biomolecular chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors at 2 institutions in 1 country.
Alexander W WeigDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. cmelande@nd.edu.
Patrick M O'ConnerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. cmelande@nd.edu.
Jakub M KwiecinskiDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. alexander.horswill@cuanschutz.edu.ORCID 0000-0001-9472-2896
Orry M MarcianoDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. cmelande@nd.edu.
Angelica NunagDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. cmelande@nd.edu.
Andrew T GutierrezDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. cmelande@nd.edu.
Roberta J MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. cmelande@nd.edu.
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. alexander.horswill@cuanschutz.edu.
Christian MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. cmelande@nd.edu.ORCID 0000-0001-8271-4696
University of Notre Dame · USUniversity of Colorado Anschutz Medical Campus · US
Funding
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
Chemistry-Biochemistry-Biology Training Program at Notre DameT32GM075762 · NIGMS · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2007 to 2021
$3.7M
Chemistry-Biochemistry-Biology Interface (CBBI) Program at Notre DameT32GM145773 · NIGMS · UNIVERSITY OF NOTRE DAME · PI Christian Corey Melander · 2022 to 2026
$1.5M
Regulation of Staphylococcus aureus colonization and diseaseR01AI141490 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HORSWILL, ALEXANDER R · 2019 to 2022
$1.5M
Quorum Sensing Dependent Interactions with Biofilms and Innate Immunity DefensesI01BX002711 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI ALEXANDER R HORSWILL · 2015 to 2026
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
A structure activity relationship study of 3,4'-dimethoxyflavone for ArlRS inhibition in · full record | OpenQuestion