Evidence map›Paper›PMID 37013172›Full record

ArticleBrain communications2023

Alteration in the number of neuronal and non-neuronal cells in mouse models of obesity.

Mayara M Andrade, Caroline Fernandes, Leticia Forny-Germano, Rafaella A Gonçalves, Michelle Gomes, Emily Castro-Fonseca, Angela M Ramos-Lobo, Fernanda Tovar-Moll, Carlos Humberto Andrade-Moraes, Jose Donato and 1 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Mayara M AndradeInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Caroline FernandesInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Leticia Forny-GermanoInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Rafaella A GonçalvesCentre for Neuroscience Studies, Departments of Biomedical and Molecular Sciences and Psychiatry, Queen's University, Kingston, ON K7L 3N6, Canada.
Michelle GomesInstitute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Emily Castro-FonsecaInstitute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Angela M Ramos-LoboDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Fernanda Tovar-MollD'Or Institute for Research and Education, Neuroscience Laboratory, Rio de Janeiro 22281-100, Brazil.
Carlos Humberto Andrade-MoraesInstitute of Medical Sciences, Federal University of Rio de Janeiro, Macaé 27930-560, Brazil.
Jose DonatoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Fernanda G De FeliceInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID https://orcid.org/0000-0001-8358-0589
Universidade Federal do Rio de Janeiro · BRUniversidade de São Paulo · BRD’Or Institute for Research and Education · BRQueen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is defined as abnormal or excessive fat accumulation that may impair health and is a risk factor for developing other diseases, such as type 2 diabetes and cardiovascular disorder. Obesity is also associated with structural and functional alterations in the brain, and this condition has been shown to increase the risk of Alzheimer's disease. However, while obesity has been associated with neurodegenerative processes, its impact on brain cell composition remains to be determined. In the current study, we used the isotropic fractionator method to determine the absolute composition of neuronal and non-neuronal cells in different brain regions of the genetic mouse models of obesity

Indexed as

isotropic fractionatorneurodegenerationneuroinflammationneuronal lossobesity

Identifiers

PMID37013172
PMCPMC10066574
OpenAlexW4328050726

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.