Evidence map›Paper›PMID 37012960›Full record

ArticleCureus2023

Association Between Follicle-Stimulating Hormone Receptor (FSHR) rs6166 and Estrogen Receptor 1 (ESR1) rs2234693 Polymorphisms and Polycystic Ovary Syndrome Risk, Phenotype, and Reproductive Outcomes in an Infertile Portuguese Population.

Inês H Vieira, Alexandra F Carvalho, Sandra Almeida Reis, Ana L Carreira, Conceição Dias, Silvana Fernandes, Ana Filipa Ferreira, Dircea Rodrigues, Ana Paula Sousa, João Ramalho-Santos and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Inês H VieiraDepartment of Endocrinology, Diabetes, and Metabolism, Coimbra Hospital and University Center, Coimbra, PRT.
Alexandra F CarvalhoReproductive Medicine Unit, Department of Gynecology, Obstetrics, Reproduction, and Neonatology, Coimbra Hospital and University Center, Coimbra, PRT.
Sandra Almeida ReisCenter for Neuroscience and Cell Biology (CNC) CIBB, University of Coimbra, Coimbra, PRT.
Ana L CarreiraDepartment of Endocrinology, Diabetes, and Metabolism, Coimbra Hospital and University Center, Coimbra, PRT.
Conceição DiasReproductive Medicine Unit, Department of Gynecology, Obstetrics, Reproduction, and Neonatology, Coimbra Hospital and University Center, Coimbra, PRT.
Silvana FernandesReproductive Medicine Unit, Department of Gynecology, Obstetrics, Reproduction, and Neonatology, Coimbra Hospital and University Center, Coimbra, PRT.
Ana Filipa FerreiraReproductive Medicine Unit, Department of Gynecology, Obstetrics, Reproduction, and Neonatology, Coimbra Hospital and University Center, Coimbra, PRT.
Dircea RodriguesDepartment of Endocrinology, Diabetes, and Metabolism, Coimbra Hospital and University Center, Coimbra, PRT.
Ana Paula SousaReproductive Medicine Unit, Department of Gynecology, Obstetrics, Reproduction, and Neonatology, Coimbra Hospital and University Center, Coimbra, PRT.
João Ramalho-SantosCenter for Neuroscience and Cell Biology (CNC), Center for Innovation in Biomedicine and Biotechnology, University of Coimbra, Coimbra, PRT.
Ana Cristina RamalhinhoHealth Sciences Research Centre (CICS-UBI), University of Beira Interior, Covilhã, PRT.
Mariana Moura RamosReproductive Medicine Unit, Department of Gynecology, Obstetrics, Reproduction, and Neonatology, Coimbra Hospital and University Center, Coimbra, PRT.
Isabel PaivaDepartment of Endocrinology, Diabetes, and Metabolism, Coimbra Hospital and University Center, Coimbra, PRT.
Paulo CortesãoReproductive Medicine Unit, Department of Gynecology, Obstetrics, Reproduction, and Neonatology, Coimbra Hospital and University Center, Coimbra, PRT.
Ana Teresa Almeida-SantosCenter for Neuroscience and Cell Biology (CNC), Center for Innovation in Biomedicine and Biotechnology, University of Coimbra, Coimbra, PRT.
University of Coimbra · PTUniversity of Beira Interior · PTCognitive Research (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPolycystic ovary syndrome (PCOS) is a common endocrine disorder often leading to anovulatory infertility. PCOS pathophysiology is still unclear and several potential genetic susceptibility factors have been proposed. The effect of polymorphisms in two genesrelated to follicular recruitment and development, the follicle-stimulating hormone receptor (

aimsTo evaluate the influence of MATERIALS AND

methodsGenotyping of the

resultsWe evaluated 88 PCOS women and 80 controls. There was no significant difference in the genotype distribution of

conclusionOur data suggest that in the population,

Indexed as

anovulationestrogenestrogen receptor (er)follicle-stimulating hormonefshfsh receptorinfertilitypolycystic ovary syndromepolycystic ovary syndrome (pcos)single-nucleotide polymorphism

Identifiers

PMID37012960
PMCPMC10066722
OpenAlexW4322767653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.