Evidence map›Paper›PMID 37012521›Full record

ArticleJournal of endocrinological investigation2023

Hashimoto's thyroiditis and renal transplant rejection.

B Sigman, D F Linder, J L Waller, W B Bollag, S L Baer, S Tran, M Kheda, L Young, A Mohammed, C M Isales and 1 more

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Efficacy and safety ofFrontiers in pharmacology · 2023
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

B SigmanMedical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.ORCID http://orcid.org/0000-0003-2177-7823
D F LinderMedical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
J L WallerMedical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
W B BollagMedical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA. wbollag@augusta.edu.
S L BaerMedical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
S TranMedical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
M KhedaMedical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
L YoungCollege of Nursing at Augusta University, Augusta, GA, USA.
A MohammedMedical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
C M IsalesMedical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
B SiddiquiMedical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
Augusta University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder that can disrupt thyroid function and homeostasis. As HT results from a dysregulated immune system, we hypothesized that these patients might be more susceptible to transplant failure; however, literature on this association is limited. The purpose of this study is to examine the association of HT with the risk of renal transplant failure.

methodsWe utilized the United States Renal Database System dataset collected from 2005 to 2014 and compared the time from first renal transplant to transplant failure in end-stage renal disease (ESRD) patients with a HT diagnosis to ESRD patients without a HT diagnosis that underwent renal transplant.

resultsA total of 144 ESRD patients had International Classification of Disease-9 claim codes for HT prior to renal transplant, amongst a total cohort of 90,301 renal transplant patients aged 18-100 and meeting criteria. Patients with HT were significantly more likely to be female, white, and to have a diagnosis of cytomegalovirus compared to patients without. ESRD patients with a HT diagnosis that underwent renal transplant had a significantly increased risk of renal transplant failure compared to those ESRD renal transplant patients without an HT diagnosis. There was a significantly increased adjusted hazard ratio for graft failure in patients with a HT diagnosis compared to those without.

conclusionThyroid health and HT may play a significant role in the development of the increased risk of renal transplant failure observed in this study. Additional studies are needed to investigate the underlying mechanisms for this association.

Indexed as

Hashimoto DiseaseKidney DiseasesKidney Failure, ChronicKidney TransplantationFemaleHumansMaleAutoimmunityHashimoto’s thyroiditisRenal transplant rejectionThyroid

Identifiers

PMID37012521
OpenAlexW4362522251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.