SynthesisNature genetics2023
Genetic effects on the timing of parturition and links to fetal birth weight.
Erratum issuedOpen access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 72 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 6 pooled it
18.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 6 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects.Nature communications · 2026Pooled it
- Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel.BMC medicine · 2026Pooled it
- Unlocking the potential of embryos: insight of systematic review and meta-analysis into laser-assisted hatching's role in conquering recurrent implantation failure.Frontiers in reproductive health · 2025Pooled it
- Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage.Nature genetics · 2024Pooled it
- Smoking during pregnancy and its effect on placental weight: a Mendelian randomization study.BMC pregnancy and childbirth · 2024Pooled it
- Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.PLoS genetics · 2023Pooled it
- Narrative Review on Therapies That Influence Inflammatory Responses During Extremely Premature Perinatal Respiratory Transition.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- AAT/SERPINA1 Pi*Z variant linked to gestational length and preterm birth prevention via AAT in mice.Nature communications · 2026Article
- Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects.Nature genetics · 2026Article
- Age at menarche and adverse pregnancy and perinatal outcomes: triangulating evidence from multivariable and Mendelian randomization analyses.International journal of epidemiology · 2026Article
- Genetic survey of biomarkers at early and mid-pregnancy identifies pregnancy-specialized immune regulation.PLoS genetics · 2026Article
- Maternal Genetic Variants and Gestational Duration: A Replication Study in a Japanese Cohort.Journal of clinical medicine · 2026Article
- GWAS-by-subtraction reveals new genetic architecture and health implications of type 2 diabetes-independent gestational diabetes mellitus.Genome medicine · 2026Article
- Using human genetics to understand the effect of modulating targets of antihypertensive drugs in pregnancy.medRxiv : the preprint server for health sciences · 2026Article
- Disentangling the relationship between intrauterine exposures and offspring growth in mid-childhood.BMC medicine · 2026Article
- Article
- The prenatal sex steroid theory of autism after 25 years.Nature human behaviour · 2026Review
- From classroom to clinic: analyzing the genomics competency gap across undergraduate students, graduate students, and practicing nurses in China.BMC nursing · 2026Article
- Testing the performance of polygenic scores for multiple traits to explain cerebral palsy in two independent cohorts.EBioMedicine · 2026Article
- Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
88 authors at 20 institutions in 11 countries.
Pol Solé-NavaisDepartment of Obstetrics and Gynaecology, Sahlgrenska Academy, Institute of Clinical Science, University of Gothenburg, Gothenburg, Sweden. pol.sole.navais@gu.se.ORCID http://orcid.org/0000-0002-3326-266X
Christopher FlatleyDepartment of Obstetrics and Gynaecology, Sahlgrenska Academy, Institute of Clinical Science, University of Gothenburg, Gothenburg, Sweden.
Valgerdur SteinthorsdottirdeCODE genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1846-6274
Marc VaudelCenter for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0003-1179-9578
Julius JuodakisDepartment of Obstetrics and Gynaecology, Sahlgrenska Academy, Institute of Clinical Science, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-5600-974X
Jing ChenDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-6227-7393
Triin LaiskEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-1501-9030
Abigail L LaBellaDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-0068-6703
David WestergaardNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0128-8432
Jonas BacelisDepartment of Obstetrics and Gynaecology, Sahlgrenska Academy, Institute of Clinical Science, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-2450-732X
Ben BrumptonK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0002-3058-1059
Line SkotteDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7398-1271
Maria C BorgesMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Øyvind HelgelandCenter for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-5612-2985
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5585-3420
Matthias WielscherDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-4138-1383
Frederick LinNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1670-6086
Catherine BriggsDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Carol A WangSchool of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID http://orcid.org/0000-0002-4301-3974
Gunn-Helen MoenK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0002-8768-0904
Robin N BeaumontInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0003-0750-8248
Jonathan P BradfieldQuantinuum Research LLC, Wayne, PA, USA.
Abin AbrahamChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Gudmar ThorleifssondeCODE genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-4623-9087
Maiken E GabrielsenK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Sisse R OstrowskiDepartment of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5288-3851
Dominika ModzelewskaDepartment of Obstetrics and Gynaecology, Sahlgrenska Academy, Institute of Clinical Science, University of Gothenburg, Gothenburg, Sweden.
Ellen A NohrResearch Unit of Gynecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Elina HypponenAustralian Centre for Precision Health, Uni Clinical & Health Sciences, University of South Australia, Adelaide, Australia.ORCID http://orcid.org/0000-0003-3670-9399
Amit SrivastavaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Octavious TalbotNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.
Catherine AllardCentre de recherche du Centre hospitalier universitaire de Sherbrooke (CHUS), Sherbrooke, Québec, Canada.ORCID http://orcid.org/0000-0002-8829-4984
Scott M WilliamsDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-4835-9544
Ramkumar MenonDepartment of Obstetrics and Gynaecology, University of Texas Medical Branch, Galveston, TX, USA.
Beverley M ShieldsInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, UK.
Gardar SveinbjornssondeCODE genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-2429-9468
Huan XuDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Mads MelbyeK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
William LoweNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9467-3422
Luigi BouchardDepartment of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Emily OkenDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Ole B PedersenDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2312-5976
Daniel F GudbjartssondeCODE genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-6551-6647
Erik SørensenDepartment of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Early Growth Genetics Consortium
Estonian Biobank Research Team
Danish Blood Donor Study Genomic Consortium
Rolv T LieCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Kari TeramoDepartment of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland.
Mikko HallmanPEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Thorhildur JuliusdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Hakon HakonarsonThe Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Henrik UllumState Serum Institute, Copenhagen, Denmark.
Andrew T HattersleyInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0001-5620-473X
Line SletnerDepartment of Pediatric and Adolescents Medicine, Akershus University Hospital, Lørenskog, Norway.
Mario MerialdiMaternal Newborn Health Innovations, PBC, Geneva, Switzerland.
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Thora SteingrimsdottirFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Denise ScholtensNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-8252-7863
Christine PowerPopulation, Policy, Practice. Great Ormond Street Institute of Child Health, University College London, London, UK.
Jane WestBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.ORCID http://orcid.org/0000-0002-5770-8363
Mette NyegaardDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.ORCID http://orcid.org/0000-0003-4973-8543
John A CapraBakar Computational Health Sciences Institute and Department of Epidemiology and Statistics, University of California San Francisco, San Francisco, CA, USA.
Anne H SkogholtK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0001-7466-0405
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Ole A AndreassenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Unnur ThorsteinsdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Struan F A GrantDepartment of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2025-5302
Elisabeth QvigstadInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Craig E PennellSchool of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID http://orcid.org/0000-0002-0937-6165
Marie-France HivertDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7752-2585
Geoffrey M HayesNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-4617-3981
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-2149-0630
Mark I McCarthyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Deborah A LawlorMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-6793-2262
Henriette S NielsenDepartment of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.ORCID http://orcid.org/0000-0003-2106-8103
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-2964-6011
Antonis RokasDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-7248-6551
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Kari StefanssondeCODE genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1676-864X
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1478-649X
Pål NjolstadCenter for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0003-0304-6728
Louis J MugliaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rachel M FreathyMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-4152-2238
Stefan JohanssonCenter for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-2298-7008
Ge Zhang *Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Bo Jacobsson *Department of Obstetrics and Gynaecology, Sahlgrenska Academy, Institute of Clinical Science, University of Gothenburg, Gothenburg, Sweden. bo.jacobsson@obgyn.gu.se.ORCID http://orcid.org/0000-0001-5079-2374
deCODE Genetics (Iceland) · ISCincinnati Children's Hospital Medical Center · USNorthwestern University · USUniversity of Copenhagen · DKHarvard University · USNorwegian Institute of Public Health · NOStatens Serum Institut · DKUniversity of Gothenburg · SEOslo University Hospital · NOUniversity of Exeter · GBCentre for Human Genetics · GBVanderbilt University · USNorwegian University of Science and Technology · NOUniversity of California, San Francisco · USAarhus University · DKAkershus University Hospital · NOBradford Teaching Hospitals NHS Foundation Trust · GBCase Western Reserve University · USCentre Hospitalier Universitaire de Sherbrooke · CAChildren's Hospital of Philadelphia · US
Funding
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6MGenome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5MDeciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5MIntegrating genomic studies of gestational duration and birth weight to understand maternal and fetal causes of adverse pregnancy outcomes and links with later diseasesR01HD101669 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI FREATHY, RACHEL, JACOBSSON, BO · 2021 to 2024
$2.1MBritish Heart Foundation AA/18/7/34219British Heart Foundation CH/F/20/90003Medical Research Council MC_PC_21038Medical Research Council MC_UU_00011/6Medical Research Council MR/P014054/1NIAID NIH HHS R01 AI153356NICHD NIH HHS R01 HD034568NICHD NIH HHS R01 HD056465NICHD NIH HHS R01 HD101669Wellcome TrustWellcome Trust WT104150Wellcome Trust WT220390
Abstract
The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration. Analysis of the parental transmitted and nontransmitted alleles (n = 136,833) shows that 15 of the gestational duration genetic variants act through the maternal genome, whereas 7 act both through the maternal and fetal genomes and 2 act only via the fetal genome. Finally, the maternal effects on gestational duration show signs of antagonistic pleiotropy with the fetal effects on birth weight: maternal alleles that increase gestational duration have negative fetal effects on birth weight. The present study provides insights into the genetic effects on the timing of parturition and the complex maternal-fetal relationship between gestational duration and birth weight.
Indexed as
ParturitionPremature BirthBirth WeightFemaleGestational AgeHumansInfant, NewbornPregnancy
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.