Evidence map›Paper›PMID 37012418›Full record

ArticleCommunications biology2023

Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential.

James R Rose, Bagdeser Akdogan-Ozdilek, Andrew R Rahmberg, Michael D Powell, Sakeenah L Hicks, Christopher D Scharer, Jeremy M Boss

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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  12. Cytotoxic CD8Frontiers in immunology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

James R Rose *Department of Microbiology and Immunology, and the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Bagdeser Akdogan-Ozdilek *Department of Microbiology and Immunology, and the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Andrew R RahmbergBarrier Immunity Section, Laboratory of Viral Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.ORCID 0000-0002-6306-4584
Michael D PowellDepartment of Microbiology and Immunology, and the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Sakeenah L HicksDepartment of Microbiology and Immunology, and the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Christopher D ScharerDepartment of Microbiology and Immunology, and the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID 0000-0001-7716-8504
Jeremy M BossDepartment of Microbiology and Immunology, and the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30322, USA. jmboss@emory.edu.ORCID 0000-0002-2432-1840
Emory University · USEmory Healthcare · USNational Institute of Allergy and Infectious Diseases · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Regulation of PD-1 gene expressionR01AI113021 · NIAID · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 2014 to 2024
$4.7M
Mechanisms of human PD-1 gene regulation in T follicular helper cellsF32AI161857 · NIAID · EMORY UNIVERSITY · PI POWELL, MICHAEL DUANE · 2021 to 2023
$200k
NIAID NIH HHS F32 AI161857NIAID NIH HHS R01 AI113021NIGMS NIH HHS T32 GM008490
6 · The paper itself

Abstract

Human memory T cells (MTC) are poised to rapidly respond to antigen re-exposure. Here, we derived the transcriptional and epigenetic programs of resting and ex vivo activated, circulating CD4

Indexed as

Memory T CellsTranscriptomeChromatinEpigenomicsHumansTranscription FactorsChromatinTranscription Factors

Identifiers

PMID37012418
PMCPMC10070634
OpenAlexW4362520630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.