ArticleNature neuroscience2023
Hippocampal spatio-predictive cognitive maps adaptively guide reward generalization.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07749378 (Investigating the Interplay of Striatal and Hippocampal Processing in Decision-Making Using Transcranial Temporal Interference Stimulation), which is not on this map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Investigating the Interplay of Striatal and Hippocampal Processing in Decision-Making Using Transcranial Temporal Interference Stimulation
Who cites it
35 citing papers in PubMed.
- Article
- Habit and the hippocampus: Model-based spatial representations without outcome-sensitive control.bioRxiv : the preprint server for biology · 2026Article
- An abstract relational map emerges in the human medial prefrontal cortex with consolidation.Current biology : CB · 2026Article
- Oxytocin modulates the neurocomputational mechanisms engaged in learning rank relationships in social networks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Article
- Action information is integrated into entorhinal representations of conceptual space and is reflected in eye movements.PLoS biology · 2026Article
- Trial-by-trial learning of successor representations in human behavior.bioRxiv : the preprint server for biology · 2025Article
- Trial-by-trial learning of successor representations in human behavior.PLoS computational biology · 2025Article
- Behavioral Timing of Interictal Spikes, But Not Rate, Correlates with Impaired Working Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Replay in the human visual cortex during brief task pauses is linked to implicit learning of successor representations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Impact of symmetry in local learning rules on predictive neural representations and generalization in spatial navigation.PLoS computational biology · 2025Article
- Empowering safer socially sensitive autonomous vehicles using human-plausible cognitive encoding.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Feature identification learning both shapes and is shaped by spatial object-similarity representations.Communications psychology · 2025Article
- Hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes.Nature communications · 2025Article
- Negative affect-driven impulsivity as hierarchical model-based overgeneralization.Trends in cognitive sciences · 2025Review
- Hippocampal output suppresses orbitofrontal cortex schema cell formation.Nature neuroscience · 2025Article
- Schemas, reinforcement learning and the medial prefrontal cortex.Nature reviews. Neuroscience · 2025Review
- Abstract rule generalization for composing novel meaning recruits a frontoparietal control network.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain forms cognitive maps of relational knowledge-an organizing principle thought to underlie our ability to generalize and make inferences. However, how can a relevant map be selected in situations where a stimulus is embedded in multiple relational structures? Here, we find that both spatial and predictive cognitive maps influence generalization in a choice task, where spatial location determines reward magnitude. Mirroring behavior, the hippocampus not only builds a map of spatial relationships but also encodes the experienced transition structure. As the task progresses, participants' choices become more influenced by spatial relationships, reflected in a strengthening of the spatial map and a weakening of the predictive map. This change is driven by orbitofrontal cortex, which represents the degree to which an outcome is consistent with the spatial rather than the predictive map and updates hippocampal representations accordingly. Taken together, this demonstrates how hippocampal cognitive maps are used and updated flexibly for inference.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.