ArticleNature biomedical engineering2023
Surgical polarimetric endoscopy for the detection of laryngeal cancer.
Article in Nature biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- Multi-contrast laser endoscopy for in vivo gastrointestinal imaging.Npj imaging · 2026Article
- CKAD-Net: class-guided key-feature aggregation and adaptive decision network for vocal cord lesion prediction.Scientific reports · 2026Article
- Intrinsically Chiral Excimers: Water-Compatible Trityl-Based Nanoparticles as Tailored Dual Emitters of Circularly Polarized Luminescence in the Vis or NIR Regions.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Superelastic Tellurium Thermoelectric Coatings for Advanced Trimodal Microsensing.Nature communications · 2026Article
- Network pharmacology-guided identification of Rabdosia rubescent as a suppressor of laryngeal cancer via MMP9-mediated extracellular matrix remodeling: integratedFrontiers in pharmacology · 2026Article
- Article
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- Active metasurface designs for lensless and detector-limited imaging.Nanophotonics (Berlin, Germany) · 2025Article
- Label-free histopathological diagnosis of frozen sections based on multi-excitation and broad-emission autofluorescence imaging.Biomedical optics express · 2025Article
- Alignment of histological and polarimetric large-scale imaging for brain tissue characterization.Journal of biomedical optics · 2025Article
- Probing the Influence of Specular Reflection and Overexposure on Backscattering Mueller Matrix Polarimetry for Tissue Imaging and Sensing.Biosensors · 2025Article
- Functional Microendoscopy Reveals Calcium Responses of Single Cells in Tracheal Tuft Cells and Kidney Podocytes.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Deep tissue sensing of chiral molecules using polarization-enhanced photoacoustics.Science advances · 2025Article
- Development and performance validation of an affordable and portable high-resolution darkfield polarization-sensitive multispectral imaging microscope for the assessment of radiation dermatitis and fibrosis.Biomedical optics express · 2025Article
- Multiplexed fiber meta-tip-based circular polarimetry for label-free pathological analysis of ischemic stroke.Neurophotonics · 2025Article
- Diagnostics and Therapy for Malignant Tumors.Biomedicines · 2024Review
- PoLambRimetry: a multispectral polarimetric atlas of lamb brain.Journal of biomedical optics · 2024Article
- Computational Polarization Imaging In Vivo through Surgical Smoke Using Refined Polarization Difference.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Polarimetric Imaging for Robot Perception: A Review.Sensors (Basel, Switzerland) · 2024Review
- Spatial analysis of polarimetric images to enhance near-surface sampling sensitivity: feasibility in demineralized teeth and other tissue-like media.Journal of biomedical optics · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The standard-of-care for the detection of laryngeal pathologies involves distinguishing suspicious lesions from surrounding healthy tissue via contrasts in colour and texture captured by white-light endoscopy. However, the technique is insufficiently sensitive and thus leads to unsatisfactory rates of false negatives. Here we show that laryngeal lesions can be better detected in real time by taking advantage of differences in the light-polarization properties of cancer and healthy tissues. By measuring differences in polarized-light retardance and depolarization, the technique, which we named 'surgical polarimetric endoscopy' (SPE), generates about one-order-of-magnitude greater contrast than white-light endoscopy, and hence allows for the better discrimination of cancerous lesions, as we show with patients diagnosed with squamous cell carcinoma. Polarimetric imaging of excised and stained slices of laryngeal tissue indicated that changes in the retardance of polarized light can be largely attributed to architectural features of the tissue. We also assessed SPE to aid routine transoral laser surgery for the removal of a cancerous lesion, indicating that SPE can complement white-light endoscopy for the detection of laryngeal cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.