ArticleNature communications2023
Unequivocal identification of two-bond heteronuclear correlations in natural products at nanomole scale by i-HMBC.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
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- The Evolving Landscape of NMR Structural Elucidation.Molecules (Basel, Switzerland) · 2026Review
- Study on the structural characteristics of nitrogen-containing compounds in co-pyrolysis tar of low rank coal usingScientific reports · 2026Article
- Computational NMR Study ofInternational journal of molecular sciences · 2025Article
- The Chemistry of Phytoplankton.Chemical reviews · 2024Review
- Computational NMR Study of Benzothienoquinoline Heterohelicenes.International journal of molecular sciences · 2024Article
- Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products.Natural product reports · 2024Review
- Conformational Analysis of 1,5-Diaryl-3-Oxo-1,4-Pentadiene Derivatives: A Nuclear Overhauser Effect Spectroscopy Investigation.International journal of molecular sciences · 2023Article
- Tandocyclinones A and B, Ether BridgedMarine drugs · 2023Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HMBC is an essential NMR experiment for determining multiple bond heteronuclear correlations in small to medium-sized organic molecules, including natural products, yet its major limitation is the inability to differentiate two-bond from longer-range correlations. There have been several attempts to address this issue, but all reported approaches suffer various drawbacks, such as restricted utility and poor sensitivity. Here we present a sensitive and universal methodology to identify two-bond HMBC correlations using isotope shifts, referred to as i-HMBC (isotope shift detection HMBC). Experimental utility was demonstrated at the sub-milligram / nanomole scale with only a few hours of acquisition time required for structure elucidation of several complex proton-deficient natural products, which could not be fully elucidated by conventional 2D NMR experiments. Because i-HMBC overcomes the key limitation of HMBC without significant reduction in sensitivity or performance, i-HMBC can be used as a complement to HMBC when unambiguous identifications of two-bond correlations are needed.
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