Evidence map›Paper›PMID 37011567›Full record

ArticleAddictive behaviors2023

The association between cannabis use and risk of non-medical pain reliever misuse onset among young adults in a legal cannabis context.

Isaac C Rhew, Vi T Le, Jason J Ramirez, Charles B Fleming, Jason R Kilmer, Miranda L M Delawalla, Brittney A Hultgren, Christine M Lee, Mary E Larimer, Katarina Guttmannova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addictive behaviors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Isaac C RhewDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: rhew@uw.edu.
Vi T LeSocial Development Research Group, University of Washington, Seattle, WA, USA. Electronic address: vtl001@uw.edu.
Jason J RamirezDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: jjramirz@uw.edu.
Charles B FlemingDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: cnbflem@uw.edu.
Jason R KilmerDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: jkilmer@uw.edu.
Miranda L M DelawallaDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: martin94@uw.edu.
Brittney A HultgrenDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: hultgren@uw.edu.
Christine M LeeDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: leecm@uw.edu.
Mary E LarimerDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: larimer@uw.edu.
Katarina GuttmannovaDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: kg27@uw.edu.

Funding

Cannabis legalization and changes in young adult substance use, related health risk behaviors, and risk factors in Washington State: Within-state variation and the role of community-level factorsR01DA047996 · NIDA · UNIVERSITY OF WASHINGTON · PI GUTTMANNOVA, KATARINA · 2019 to 2021
$858k
NIDA NIH HHS R01 DA047996
6 · The paper itself

Abstract

backgroundLittle is known about the prospective relationship between cannabis use and pain reliever misuse. This study examined associations of non-medical and medical cannabis use with onset of non-medical pain reliever misuse among young adults in Washington State (WA), where non-medical cannabis is legal.

methodsData were from a cohort-sequential study of adults 18-25 residing in WA. Four annual surveys were used from cohorts recruited in 2014, 2015, and 2016. Participants who had not reported non-medical pain reliever misuse at baseline were included in discrete time survival analyses (N = 4,236). Odds ratios (ORs) were estimated for new onset of non-medical pain reliever misuse in any given follow-up year over the course of three years according to baseline non-medical and medical cannabis use.

resultsWhen included separately in models, non-medical and medical cannabis use at baseline were associated with increased risk of non-medical pain reliever misuse adjusting for demographic characteristics as well as past year cigarette use and alcohol use (non-medical OR = 5.27; 95 % CI: 3.28, 8.48; medical OR = 2.21; 95 % CI: 1.39, 3.52). Including both forms of use in the model, associations of non-medical and medical cannabis use with non-medical pain reliever misuse onset remained (non-medical OR = 4.64; 95 % CI: 2.88, 7.49; medical OR = 1.65; 95 % CI: 1.04, 2.62).

conclusionsDespite claims that cannabis use may reduce opioid use and related harms, findings suggest that cannabis use, including medical use, may not be protective, but instead may increase risk for non-medical pain reliever misuse.

Indexed as

CannabisMedical MarijuanaOpioid-Related DisordersPrescription Drug MisuseAnalgesics, OpioidHumansPainProspective StudiesYoung AdultAnalgesics, OpioidMedical MarijuanaCannabisPrescription opioid misuseYoung adults

Identifiers

PMID37011567
PMCPMC10168644

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.