Evidence map›Paper›PMID 37011218›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Whole-genome sequences from wild-type and laboratory-evolved strains define the alleleome and establish its hallmarks.

Edward Alexander Catoiu, Patrick Phaneuf, Jonathan Monk, Bernhard O Palsson

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Multi-strain analysis ofmSystems · 2026
    Article
  3. Article
  4. Multi-strain Analysis ofbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. DiarrheagenicInternational journal of molecular sciences · 2024
    Article
  7. Article
  8. Article
  9. NAR genomics and bioinformatics · 2024
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Edward Alexander CatoiuDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92101.ORCID 0000-0001-8680-7291
Patrick PhaneufThe Novo Nordisk Foundation (NNF) Center for Biosustainability, The Technical University of Denmark, Kongens Lyngby 2800, Denmark.ORCID 0000-0002-4122-6589
Jonathan MonkAvellino Lab, Menlo Park, CA 94025.ORCID 0000-0002-3895-8949
Bernhard O PalssonDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92101.ORCID 0000-0003-2357-6785

Funding

GENOMICALLY BASED MODELS FOR ANTIBIOTIC DEVELOPMENTR01GM057089 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 1998 to 2021
$6.9M
NIGMS NIH HHS R01 GM057089
6 · The paper itself

Abstract

The genomic diversity across strains of a species forms the genetic basis for differences in their behavior. A large-scale assessment of sequence variation has been made possible by the growing availability of strain-specific whole-genome sequences (WGS) and with the advent of large-scale databases of laboratory-acquired mutations. We define the

Indexed as

Escherichia coliGenetic VariationAmino Acid SequenceGenome, BacterialMutationalignmentallelelaboratory evolutionmutationsequence

Identifiers

PMID37011218
PMCPMC10104531

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.