ArticlePLoS pathogens2023
Evolutionary dynamics of dengue virus in India.
Article in PLoS pathogens, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Computational discovery of DENV-3 RdRp allosteric inhibitors: biological evaluation and mechanistic studies.Molecular diversity · 2026Article
- History, Virology, Pathogenesis, Epidemiology, and Laboratory Diagnosis of Dengue Virus: A Focused Review.Cureus · 2026Review
- Evolutionary dynamics and impact of genetic diversity of co-circulating multiple dengue serotypes among severe and non-severe cases in Kolkata, Eastern India during 2020-2022.Archives of microbiology · 2026Article
- Dengue transmission dynamics in an urban setting in western India.PLoS neglected tropical diseases · 2026Article
- Spatio-temporal analysis of dengue outbreaks in India (2021-2025): evidence from the secondary analysis of Integrated Disease Surveillance Programme.BMJ public health · 2026Article
- Tracking the clinico-microbiological profile and molecular characterization of dengue cases during the monsoon-season in Belagavi, Karnataka.PLoS neglected tropical diseases · 2026Observational
- Extending the temporal window of arbovirus evolutionary analysis through the recovery of a century-old bandavirus.Virus evolution · 2026Article
- Evolutionary history and transmission dynamics of dengue virus type 2 in Africa.Frontiers in microbiology · 2026Article
- Article
- Molecular epidemiology and evolutionary trends of dengue virus serotype-2 strains in Sri Lanka.BMC microbiology · 2025Article
- Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in Colombia.medRxiv : the preprint server for health sciences · 2025Article
- Estimating dengue force of infection from age-stratified surveillance data in Java, Indonesia.Journal of the Royal Society, Interface · 2025Article
- Correlation of clinical, biochemical and molecular profile of dengue with disease severity.Virusdisease · 2025Article
- Dengue virus: structure, genome, evolution and challenges to control and prevent transmission.Antonie van Leeuwenhoek · 2025Review
- Impact of urban heat island effect on dengue incidence: a remote sensing approach using thermal and high-resolution optical imagery.BMC public health · 2025Article
- Development of an affordable multiplex quantitative RT-PCR assay for early detection and surveillance of Dengue, Chikungunya, and co-infections from clinical samples in resource-limited settings.PLoS neglected tropical diseases · 2025Article
- Clinico-Epidemiological Profile of Dengue in Children of Age Group 0-14 Years Admitted in a Tertiary Care Hospital.Cureus · 2025Article
- Review
- Annual global dengue dynamics are related to multi-source factors revealed by a machine learning prediction analysis.PLoS neglected tropical diseases · 2025Article
- Clinico-genomic study reveals association of dengue virus genome high frequency mutations with dengue disease severity.Scientific reports · 2025Article
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5 authors.
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Abstract
More than a hundred thousand dengue cases are diagnosed in India annually, and about half of the country's population carries dengue virus-specific antibodies. Dengue propagates and adapts to the selection pressures imposed by a multitude of factors that can lead to the emergence of new variants. Yet, there has been no systematic analysis of the evolution of the dengue virus in the country. Here, we present a comprehensive analysis of all DENV gene sequences collected between 1956 and 2018 from India. We examine the spatio-temporal dynamics of India-specific genotypes, their evolutionary relationship with global and local dengue virus strains, interserotype dynamics and their divergence from the vaccine strains. Our analysis highlights the co-circulation of all DENV serotypes in India with cyclical outbreaks every 3-4 years. Since 2000, genotype III of DENV-1, cosmopolitan genotype of DENV-2, genotype III of DENV-3 and genotype I of DENV-4 have been dominating across the country. Substitution rates are comparable across the serotypes, suggesting a lack of serotype-specific evolutionary divergence. Yet, the envelope (E) protein displays strong signatures of evolution under immune selection. Apart from drifting away from its ancestors and other contemporary serotypes in general, we find evidence for recurring interserotype drift towards each other, suggesting selection via cross-reactive antibody-dependent enhancement. We identify the emergence of the highly divergent DENV-4-Id lineage in South India, which has acquired half of all E gene mutations in the antigenic sites. Moreover, the DENV-4-Id is drifting towards DENV-1 and DENV-3 clades, suggesting the role of cross-reactive antibodies in its evolution. Due to the regional restriction of the Indian genotypes and immunity-driven virus evolution in the country, ~50% of all E gene differences with the current vaccines are focused on the antigenic sites. Our study shows how the dengue virus evolution in India is being shaped in complex ways.
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