Evidence map›Paper›PMID 37010807›Full record

ArticleMolecular neurobiology2023

Inflammasome-Mediated Neuronal-Microglial Crosstalk: a Therapeutic Substrate for the Familial C9orf72 Variant of Frontotemporal Dementia/Amyotrophic Lateral Sclerosis.

Kyle J Trageser, Eun-Jeong Yang, Chad Smith, Ruth Iban-Arias, Tatsunori Oguchi, Maria Sebastian-Valverde, Umar Haris Iqbal, Henry Wu, Molly Estill, Md Al Rahim and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Microglia in Neurodegenerative Diseases.Advances in neurobiology · 2024
    Review
  12. Article
  13. Moderate intrinsic phenotypic alterations inFrontiers in cellular neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Kyle J TrageserDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Eun-Jeong YangDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Chad SmithDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ruth Iban-AriasDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Tatsunori OguchiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Maria Sebastian-ValverdeDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Umar Haris IqbalDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Henry WuDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Molly EstillDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Md Al RahimDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Urdhva RavalDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Francis J HermanDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Yong Jie ZhangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Giulio Maria PasinettiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. giulio.pasinetti@mssm.edu.ORCID http://orcid.org/0000-0002-1524-5196
Icahn School of Medicine at Mount Sinai · USMayo Clinic in Florida · USGeriatric Research Education and Clinical Center · US

Funding

Suppression of Immune Signatures of Stress by Polyphenols SupplementsU19AT010835 · NCCIH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SIMON, JAMES E · 2020 to 2024
$6.8M
NCCIH NIH HHS U19AT010835
6 · The paper itself

Abstract

Intronic G

Indexed as

Amyotrophic Lateral SclerosisFrontotemporal DementiaAnimalsC9orf72 ProteinDipeptidesDNA Repeat ExpansionInflammasomesMiceMicrogliaNeuroinflammatory DiseasesNLR Family, Pyrin Domain-Containing 3 ProteinC9orf72 ProteinDipeptidesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAmyotrophic lateral sclerosisC9orf72Frontotemporal dementiaInflammasomeMicrogliaNeurodegenerationNeuroinflammation

Identifiers

PMID37010807
OpenAlexW4362507070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.