Evidence map›Paper›PMID 37010784›Full record

ArticleJournal of the American Geriatrics Society2023

Distressing symptoms after major surgery among community-living older persons.

Thomas M Gill, Ling Han, Terrence E Murphy, Shelli L Feder, Evelyne A Gahbauer, Linda Leo-Summers, Robert D Becher

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Thomas M GillDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-6450-0368
Ling HanDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Terrence E MurphyDepartment of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania, USA.ORCID 0000-0002-9649-517X
Shelli L FederYale School of Nursing, Orange, Connecticut, USA.ORCID 0000-0002-8059-9281
Evelyne A GahbauerDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Linda Leo-SummersDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Robert D BecherDepartment of Surgery, Yale School of Medicine, New Haven, Connecticut, USA.
Yale University · USPennsylvania State University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
VULNERABILITY, INTERVENING EVENTS &DISABILITY IN AGINGR01AG017560 · NIA · YALE UNIVERSITY · PI GILL, THOMAS MICHAEL · 2000 to 2025
$7.0M
A Multifactorial Approach to Evaluating Disparities in Outcomes after Major Surgery in Disadvantaged Older PersonsR01MD017298 · NIMHD · YALE UNIVERSITY · PI BECHER, ROBERT DAVID, GILL, THOMAS MICHAEL · 2022 to 2025
$2.6M
Evaluating the Implementation of Specialist Palliative Care for Patients with Advanced Heart FailureR56HL166523 · NHLBI · YALE UNIVERSITY · PI FEDER, SHELLI LEORE · 2023 to 2023
$571k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS L30 HL159709NHLBI NIH HHS R56 HL166523NIA NIH HHS P30 AG021342NIA NIH HHS R01 AG017560NIMHD NIH HHS R01 MD017298
6 · The paper itself

Abstract

backgroundRelatively little is known about how distressing symptoms change among older persons in the setting of major surgery. Our objective was to evaluate changes in distressing symptoms after major surgery and determine whether these changes differ according to the timing of surgery (nonelective vs. elective), sex, multimorbidity, and socioeconomic disadvantage.

methodsFrom a prospective longitudinal study of 754 nondisabled community-living persons, 70 years of age or older, 368 admissions for major surgery were identified from 274 participants who were discharged from the hospital from March 1998 to December 2017. The occurrence of 15 distressing symptoms was ascertained in the month before and 6 months after major surgery. Multimorbidity was defined as more than two chronic conditions. Socioeconomic disadvantage was assessed at the individual level, based on Medicaid eligibility, and neighborhood level, based on an area deprivation index (ADI) score above the 80th state percentile.

resultsIn the month before major surgery, the occurrence and mean number of distressing symptoms were 19.6% and 0.75, respectively. In multivariable analyses, the rate ratios, denoting proportional increases in the 6 months after major surgery relative to presurgery values, were 2.56 (95% confidence interval [CI], 1.91-3.44) and 2.90 (95% CI, 2.01-4.18) for the occurrence and number of distressing symptoms, respectively. The corresponding values were 3.54 (95% CI, 2.06-6.08) and 4.51 for nonelective surgery (95% CI, 2.32-8.76) and 2.12 (95% CI, 1.53-2.92) and 2.20 (95% CI, 1.48-3.29) for elective surgery; p-values for interaction were 0.030 and 0.009. None of the other subgroup differences were statistically significant, although men had a greater proportional increase in the occurrence and number of distressing symptoms than women.

conclusionsAmong community-living older persons, the burden of distressing symptoms increases substantially after major surgery, especially in those having nonelective procedures. Reducing symptom burden has the potential to improve quality of life and enhance functional outcomes after major surgery.

Indexed as

HospitalizationQuality of LifeAgedAged, 80 and overFemaleHumansLongitudinal StudiesMalePatient DischargeProspective Studiescohort studysurgerysymptoms

Identifiers

PMID37010784
PMCPMC10524276
OpenAlexW4362506237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.