Evidence map›Paper›PMID 37010659›Full record

ArticleJournal of experimental orthopaedics2023

In vitro analysis and in vivo assessment of fracture complications associated with use of locking plate constructs for stabilization of caprine tibial segmental defects.

Kristin M Bowers, Ellis M Wright, Lori D Terrones, Xiaocun Sun, Rebecca Rifkin, Remi Grzeskowiak, Elizabeth Croy, Reza Seddighi, Stephanie Kleine, Chiara Hampton and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental orthopaedics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Kristin M BowersLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA. kbower17@vols.utk.edu.ORCID http://orcid.org/0000-0002-0536-5135
Ellis M WrightSmall Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Lori D TerronesLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Xiaocun SunOffice of Information Technology, University of Tennessee, Knoxville, USA.
Rebecca RifkinLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Remi GrzeskowiakLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Elizabeth CroyLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Reza SeddighiLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Stephanie KleineSmall Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Chiara HamptonLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Silke HechtSmall Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Henry S AdairLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
David E AndersonLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Pierre-Yves MulonLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
Knoxville College · USUniversity of Tennessee at Knoxville · US

Funding

U.S. Army Medical Research Acquisition Activity W81XWH-15-1-0666U.S. Army Medical Research Acquisition Activity W81XWH-19-2-0014
6 · The paper itself

Abstract

purposeLocking plate fixation of caprine tibial segmental defects is widely utilized for translational modeling of human osteopathology, and it is a useful research model in tissue engineering and orthopedic biomaterials research due to its inherent stability while maintaining unobstructed visualization of the gap defect and associated healing. However, research regarding surgical technique and long-term complications associated with this fixation method are lacking. The goal of this study was to assess the effects of surgeon-selected factors including locking plate length, plate positioning, and relative extent of tibial coverage on fixation failure, in the form of postoperative fracture.

methodsIn vitro, the effect of plate length was evaluated using single cycle compressive load to failure mechanical testing of locking plate fixations of caprine tibial gap defects. In vivo, effects of plate length, positioning, and relative tibial coverage were evaluated using data from a population of goats enrolled in ongoing orthopedic research which utilized locking plate fixation of 2 cm tibial diaphyseal segmental defects to evaluate bone healing over 3, 6, 9, and 12 months.

resultsIn vitro, no significant differences in maximum compressive load or total strain were noted between fixations using 14 cm locking plates and 18 cm locking plates. In vivo, both plate length and tibial coverage ratio were significantly associated with postoperative fixation failure. The incidence of any cortical fracture in goats stabilized with a 14 cm plate was 57%, as compared with 3% in goats stabilized with an 18 cm plate. Craniocaudal and mediolateral angular positioning variables were not significantly associated with fixation failure. Decreasing distance between the gap defect and the proximal screw of the distal bone segment was associated with increased incidence of fracture, suggesting an effect on proximodistal positioning on overall fixation stability.

conclusionsThis study emphasizes the differences between in vitro modeling and in vivo application of surgical fixation methods, and, based on the in vivo results, maximization of plate-to-tibia coverage is recommended when using locking plate fixation of the goat tibial segmental defect as a model in orthopedic research.

Indexed as

CaprineLocking plate fixationPlate lengthTibiaWorking length

Identifiers

PMID37010659
PMCPMC10070588
OpenAlexW4362520600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.