Evidence map›Paper›PMID 37010579›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

Somatostatin receptor activity assessed by

Paola Mapelli, Carolina Bezzi, Francesca Muffatti, Samuele Ghezzo, Francesco Baldassi, Marco Schiavo Lena, Valentina Andreasi, Carla Canevari, Patrizia Magnani, Francesco De Cobelli and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Paola Mapelli *Vita-Salute San Raffaele University, Milan, Italy.
Carolina Bezzi *Vita-Salute San Raffaele University, Milan, Italy.
Francesca MuffattiPancreatic Surgery Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Samuele GhezzoVita-Salute San Raffaele University, Milan, Italy.
Francesco BaldassiUniversity of Milano-Bicocca, Milan, Italy.
Marco Schiavo LenaPathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Valentina AndreasiVita-Salute San Raffaele University, Milan, Italy.
Carla CanevariNuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Patrizia MagnaniNuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Francesco De CobelliVita-Salute San Raffaele University, Milan, Italy.
Luigi GianolliNuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Stefano PartelliVita-Salute San Raffaele University, Milan, Italy.
Massimo FalconiVita-Salute San Raffaele University, Milan, Italy.
Maria PicchioVita-Salute San Raffaele University, Milan, Italy. picchio.maria@hsr.it.ORCID http://orcid.org/0000-0002-7532-6211
Vita-Salute San Raffaele University · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the role of

methodsThis retrospective study included 72 consecutive patients with PanNET (January 2018-March 2022) who underwent to

resultsForty-two/72 patients had a G1, 28/72 a G2, and 2/72 a G3 PanNET. Seven/72 patients had DAXX LoE, 10/72 ATRX LoE, and 2/72 DAXX/ATRX LoE. SRD and TLSRD could predict DAXX LoE (p = 0.002, p = 0.018, respectively). By evaluating SRD in combination with radiological diameter, only SRD maintained statistical significance (multivariate logistic regression: p = 0.020, OR = 1.05), providing the best prediction (AUC-ROC = 79.01%; cut-off = 46.96; sensitivity = 77.78%; specificity = 88.89%). In the sub-analysis performed on 55 patients with biopsy availability, SRD demonstrated its role in providing useful and additional information (multivariate logistic regression: SRD p = 0.007; grade p = 0.040).

conclusionSRD has a predictive role on DAXX LoE in PanNETs, with higher probability of LoE at increasing SRD values. SRD provides complementary/additional information to grade assessed on biopsy material, and the combined use of these approaches might support patients' management by preoperatively identifying subjects with more aggressive diseases.

Indexed as

Neuroendocrine TumorsPancreatic NeoplasmsAdaptor Proteins, Signal TransducingCo-Repressor ProteinsGallium RadioisotopesHumansMolecular ChaperonesOctreotidePositron-Emission TomographyReceptors, SomatostatinRetrospective StudiesX-linked Nuclear ProteinAdaptor Proteins, Signal TransducingATRX protein, humanCo-Repressor ProteinsDAXX protein, humanEdotreotideGallium RadioisotopesMolecular ChaperonesOctreotideReceptors, SomatostatinX-linked Nuclear Protein68Ga-DOTA-peptidesATRXDAXXPancreatic neuroendocrine tumorPETPredictive valuePreoperativeRisk assessmentSomatostatin receptor activity

Identifiers

PMID37010579
OpenAlexW4362505951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.