Evidence map›Paper›PMID 37010416›Full record

ArticleMicrobiology spectrum2023

Strict Conservation yet Non-Essential Nature of Plasmid Gene

Irene N Kasumba, Kit Tilly, Tao Lin, Steven J Norris, Patricia A Rosa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Irene N KasumbaLaboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Kit TillyLaboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Tao LinDepartment of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, USA.
Steven J NorrisDepartment of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, USA.ORCID 0000-0002-2501-8034
Patricia A RosaLaboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.ORCID 0000-0002-9489-3406
National Institutes of Health · US

Funding

Molecular Genetic Basis of the Infectious Cycle of Borrelia burgdorferiZIAAI000917 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ROSA, PATRICIA A · 2009 to 2023
$13.7M
Virulence Determinants of Borrelia burgdorferiR01AI059048 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI NORRIS, STEVEN J. · 2004 to 2016
$5.3M
NIAID NIH HHS R01 AI059048
6 · The paper itself

Abstract

The highly segmented genome of Borrelia burgdorferi, the tick-borne bacterium that causes Lyme disease, is composed of a linear chromosome and more than 20 co-existing endogenous plasmids. Many plasmid-borne genes are unique to B. burgdorferi and some have been shown to provide essential functions at discrete points of the infectious cycle between a tick vector and rodent host. In this study, we investigated the role of

Indexed as

Borrelia burgdorferiIxodesLyme DiseaseAnimalsMicePlasmidsBorrelia burgdorferigene conservationplasmidstick-borne pathogen

Identifiers

PMID37010416
PMCPMC10269632
OpenAlexW4362506086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.