Evidence map›Paper›PMID 37010385›Full record

ArticleClinical toxicology (Philadelphia, Pa.)2023

The vitamin B

John Tat, Stephen C Chang, Cole D Link, Suelen Razo-Lopez, Michael J Ingerto, Behdod Katebian, Adriano Chan, Hema Kalyanaraman, Renate B Pilz, Gerry R Boss

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical toxicology (Philadelphia, Pa.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

John TatDepartment of Medicine, University of California, San Diego, CA, USA.
Stephen C ChangDepartment of Medicine, University of California, San Diego, CA, USA.
Cole D LinkDepartment of Medicine, University of California, San Diego, CA, USA.
Suelen Razo-LopezDepartment of Medicine, University of California, San Diego, CA, USA.
Michael J IngertoDepartment of Medicine, University of California, San Diego, CA, USA.
Behdod KatebianDepartment of Medicine, University of California, San Diego, CA, USA.
Adriano ChanDepartment of Medicine, University of California, San Diego, CA, USA.
Hema KalyanaramanDepartment of Medicine, University of California, San Diego, CA, USA.
Renate B PilzDepartment of Medicine, University of California, San Diego, CA, USA.
Gerry R BossDepartment of Medicine, University of California, San Diego, CA, USA.
University of California, San Diego · US

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying AgentU01NS058030 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2006 to 2017
$7.3M
Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide AntidoteU01NS087964 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2015 to 2019
$4.3M
Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical ThreatsR21NS072105 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2011 to 2012
$774k
NIGMS NIH HHS K12 GM068524NINDS NIH HHS P30 NS047101NINDS NIH HHS R21 NS072105NINDS NIH HHS U01 NS058030NINDS NIH HHS U01 NS087964
6 · The paper itself

Abstract

contextThe azide anion (N

resultsWe found cobinamide bound azide with a moderate affinity (K

conclusionWe conclude cobinamide likely acted by neutralizing both oxidative stress and nitric oxide, and that it should be given further consideration as an azide antidote.

Indexed as

HypotensionVitamin B 12Adenosine TriphosphateAnimalsAntidotesAzidesCobamidesDrosophila melanogasterElectron Transport Complex IVMammalsMiceNitric OxideVitaminsAdenosine TriphosphateAntidotesAzidesCobamidescobinamideElectron Transport Complex IVNitric OxideVitamin B 12Vitaminsazide poisoningoxidative stressSodium azidesurvival treatment

Identifiers

PMID37010385
PMCPMC10348668
OpenAlexW4362505899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.