ArticleeLife2023
Spatiotemporal tissue maturation of thalamocortical pathways in the human fetal brain.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.bioRxiv : the preprint server for biology · 2026Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- A motor thalamic site in humans that suppresses involuntary breathing without awareness.Journal of neurophysiology · 2026Article
- The Fronto-Temporal Cortex Has Increased Subcortical Connectivity In Utero and Plasticity in Adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dysfunctional brain connectivity and cognition in late preterm infants: novel perspectives on neurodevelopment and learning.Frontiers in synaptic neuroscience · 2026Review
- Transcriptomic divergence of network hubs in the prenatal human brain.Communications biology · 2025Article
- Dissecting mammalian cortical circuit development at single-cell resolution using inducible barcoded rabies virus.bioRxiv : the preprint server for biology · 2025Article
- Early Development and Co-Evolution of Microstructural and Functional Brain Connectomes: A Multi-Modal MRI Study in Preterm and Full-Term Infants.Human brain mapping · 2025Article
- Perinatal development of structural thalamocortical connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Development of the basic architecture of neocortical circuitry in the human fetus as revealed by the coupling spatiotemporal pattern of synaptogenesis along with microstructure and macroscale in vivo MR imaging.Brain structure & function · 2024Article
- Heterogeneity in the formation of primary and secondary visual fields during human prenatal development.Biological research · 2024Article
- Structural Covariance Networks in the Fetal Brain Reveal Altered Neurodevelopment for Specific Subtypes of Congenital Heart Disease.Journal of the American Heart Association · 2024Article
- Anatomically constrained tractography of the fetal brain.NeuroImage · 2024Article
- Advances in Fetal Brain Imaging.Magnetic resonance imaging clinics of North America · 2024Review
- Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo.bioRxiv : the preprint server for biology · 2024Article
- Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging.Cold Spring Harbor perspectives in biology · 2024Review
- Characterizing microstructural development in the fetal brain using diffusion MRI from 23 to 36 weeks of gestation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Editorial: The earliest-born cortical neurons as multi-tasking pioneers: expanding roles for subplate neurons in cerebral cortex organization and function, volume II.Frontiers in neuroanatomy · 2023Article
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Authors and funding
18 authors.
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Abstract
The development of connectivity between the thalamus and maturing cortex is a fundamental process in the second half of human gestation, establishing the neural circuits that are the basis for several important brain functions. In this study, we acquired high-resolution in utero diffusion magnetic resonance imaging (MRI) from 140 fetuses as part of the Developing Human Connectome Project, to examine the emergence of thalamocortical white matter over the second to third trimester. We delineate developing thalamocortical pathways and parcellate the fetal thalamus according to its cortical connectivity using diffusion tractography. We then quantify microstructural tissue components along the tracts in fetal compartments that are critical substrates for white matter maturation, such as the subplate and intermediate zone. We identify patterns of change in the diffusion metrics that reflect critical neurobiological transitions occurring in the second to third trimester, such as the disassembly of radial glial scaffolding and the lamination of the cortical plate. These maturational trajectories of MR signal in transient fetal compartments provide a normative reference to complement histological knowledge, facilitating future studies to establish how developmental disruptions in these regions contribute to pathophysiology.
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