ArticlePsychological medicine2023
Disorder-specific cingulo-opercular network hyperconnectivity in pediatric OCD relative to pediatric anxiety.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Brain Network Abnormalities in Obsessive-Compulsive Disorder: Insights from Edge Functional Connectivity Analysis.Behavioral sciences (Basel, Switzerland) · 2025Article
- Neural Markers of Treatment Response in Pediatric Anxiety and PTSD.Current topics in behavioral neurosciences · 2025Review
- In the face of ambiguity: intrinsic brain organization in development predicts one's bias toward positivity or negativity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic.Neurobiology of stress · 2023Article
- Network Structure of Autism Spectrum Disorder Behaviors and Its Evolution in Preschool Children: Insights from a New Longitudinal Network Analysis Method.Journal of autism and developmental disorders · 2023Article
- Defining brain-based OCD patient profiles using task-based fMRI and unsupervised machine learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Altered spatio-temporal state patterns for functional dynamics estimation in first-episode drug-naive major depression.Brain imaging and behavior · 2022Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundPrior investigation of adult patients with obsessive compulsive disorder (OCD) has found greater functional connectivity within orbitofrontal-striatal-thalamic (OST) circuitry, as well as altered connectivity within and between large-scale brain networks such as the cingulo-opercular network (CON) and default mode network (DMN), relative to controls. However, as adult OCD patients often have high rates of co-morbid anxiety and long durations of illness, little is known about the functional connectivity of these networks in relation to OCD specifically, or in young patients near illness onset.
methodsIn this study, unmedicated female patients with OCD (ages 8-21 years,
resultsFunctional connectivity within the CON was significantly greater in the OCD group as compared to the anxiety and healthy control groups. Additionally, the OCD group displayed greater functional connectivity between OST and CON compared to the other two groups, which did not differ significantly from each other.
conclusionsOur findings indicate that previously noted network connectivity differences in pediatric patients with OCD were likely not attributable to co-morbid anxiety disorders. Moreover, these results suggest that specific patterns of hyperconnectivity within CON and between CON and OST circuitry may characterize OCD relative to non-OCD anxiety disorders in youth. This study improves understanding of network dysfunction underlying pediatric OCD as compared to pediatric anxiety.
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