ArticlePsychological medicine2023
Genetic liability to suicide attempt, suicide death, and psychiatric and substance use disorders on the risk for suicide attempt and suicide death: a Swedish national study.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Predicting the geographical distribution of drug use disorder in Sweden from the geographical variation in social deprivation, genetic risk and urbanization.Molecular psychiatry · 2026Article
- Leveraging Family Genetic Risk Scores to Understand the Etiology of Suicidal Behaviors and Their Associations With Psychiatric Disorders.Acta psychiatrica Scandinavica · 2026Article
- Lifetime substance use disorder and suicidal behaviour: a population-based familial co-aggregation register study.Molecular psychiatry · 2026Article
- Suicidality phenotypes reflect both shared and distinct genetic factors.medRxiv : the preprint server for health sciences · 2026Article
- The relationship in women between genetic liability and the risk of onset of alcohol use disorder while pregnant or rearing an infant, toddler, or preschool child.Molecular psychiatry · 2026Article
- The protective effect of pregnancy on risk for suicide attempt in a Swedish national cohort.Scientific reports · 2026Article
- Sex differences in familial risk and genetic components of suicide attempts: a register-based cohort study in Sweden.BMJ mental health · 2026Article
- The Impact of a Registry-Based Environmental Risk Score on Episodes of Alcohol Use Disorder and Drug Use Disorder in Swedish National Samples.Journal of studies on alcohol and drugs · 2026Article
- Association Between Trauma, Impulsivity, and Functioning in Suicide Attempters.Behavioral sciences (Basel, Switzerland) · 2025Article
- Parental Diseases of Despair and Suicidal Events in Their Children.JAMA network open · 2025Article
- Exploring the implications of case selection methods for psychiatric molecular genetic studies.Molecular psychiatry · 2025Article
- The moderation of genetic risk for ten major psychiatric and substance use disorders by the genetic aptitude for educational attainment.Molecular psychiatry · 2025Article
- The Prediction of Diagnostic Change From Bipolar Disorder to Schizophrenia and Schizophrenia to Bipolar Disorder in a Population-Based, Longitudinal, National Swedish Sample.Schizophrenia bulletin · 2025Article
- Uncovering Genetic Risk Beyond Diagnoses in Suicidal Thoughts and Behaviors: Insights frommedRxiv : the preprint server for health sciences · 2025Article
- The development of an environmental risk score using Swedish National Registers and its impact on subsequent episodes of major depression.Psychological medicine · 2025Article
- Risk factors, impact, and healthcare use related to initial suicide attempts: comprehensive analysis of Swedish population.BMJ medicine · 2025Article
- The impact of family-genetic risk scores on social functioning in individuals affected with six major psychiatric and substance use disorders in a Swedish National Sample.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2024Article
- The geographical distribution of the family-genetic risk score for drug use disorder in Sweden and its co-localization with areas of social deprivation.Psychological medicine · 2024Article
- Age at onset as an index of genetic heterogeneity in major psychiatric and substance use disorders.Psychological medicine · 2024Article
- Peer Social Genetic Effects and the Etiology of Substance Use Disorders, Major Depression, and Anxiety Disorder in a Swedish National Sample.The American journal of psychiatry · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHow does genetic liability to suicide attempt (SA), suicide death (SD), major depression (MD), bipolar disorder (BD), schizophrenia (SZ), alcohol use disorder (AUD), and drug use disorder (DUD) impact on risk for SA and SD?
methodsIn the Swedish general population born 1932-1995 and followed through 2017 (
resultsIn univariate and multivariate models predicting SA, FGRS were highest for SA, AUD, DUD, and MD. In univariate models predicting SD, the strongest FGRS were AUD, DUD, SA, and SD. In multivariate models, the FGRS for SA and AUD were higher in predicting SA while the FGRS for SD, BD, and SZ were higher in predicting SD. Higher FGRS for all disorders significantly predicted both younger age at first SA and frequency of attempts. For SD, higher FGRS for MD, AUD, and SD predicted later age at SD. Mediation of FGRS effects on SA and SD was more pronounced for SD than SA, strongest for AUD, DUD, and SZ FGRS and weakest for MD.
conclusionsFGRS for both SA and SD and for our five psychiatric disorders impact on risk for SA and SD in a complex manner. While some of the impact of genetic risk factors for psychiatric disorders on risk for SA and SD is mediated through developing the disorders, these risks also predispose directly to suicidal behaviors.
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