Evidence map›Paper›PMID 37010198›Full record

Trial reportEuropean endodontic journal2023

Analgesic Efficacy of Ibuprofen and Diclofenac Potassium on Postoperative Endodontic Pain in Maxillary and Mandibular First Molars with Irreversible Pulpitis: A Randomised Controlled Trial.

Mohammadreza Vatankhah, Nazanin Zargar, Mandana Naseri, Saba Salem, Alireza Akbarzadeh Baghban, Ayeh Etemadi, Omid Dianat

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European endodontic journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07281807 (Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07281807 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars

TypeinterventionalSponsorRANA AHMADRan2026 to 2027Enrolled60ConditionsIrreversible Pulpitis With Apical Periodontitis, Symptomatic Apical PeriodontitisArmsGroup B: patients will be given prednisolone 20mg as premedication, piroxicam 20mg
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mohammadreza VatankhahIranian Center for Endodontic Research, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nazanin ZargarDepartment of Endodontics, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mandana NaseriDepartment of Endodontics, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saba SalemPrivate Office, Tehran, Iran.
Alireza Akbarzadeh BaghbanProteomics Research Center, Faculty of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ayeh EtemadiDepartment of Endodontics, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Omid DianatDivision of Endodontics, Department of Advanced Oral Sciences and Therapeutics, University of Maryland, Baltimore, Maryland, USA.
Shahid Beheshti University of Medical Sciences · IRUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe management of postoperative endodontic pain (PEP) is essential to contemporary endodontic practice. Diclofenac and ibuprofen (IBU) are two of the most widely-used non-steroidal anti-inflammatory analgesics. However, their comparative data are neither sufficient nor conclusive. This prospective randomised clinical trial aimed to compare the analgesic efficacy of diclofenac potassium (DFK) with IBU on PEP in maxillary and mandibular first molars diagnosed with irreversible pulpitis after single-visit non-surgical root canal treatment.

methodsSixty-four patients were randomised into two groups of DFK (n=32) and IBU (n=32), using the stratified permuted randomisation method, and 61 participants completed the trial. After root canal treatment, patients randomly received IBU 400 mg every 6 hours (n=31) or DFK 50 mg every 8 hours (n=30) for 24 hours. Patients recorded their pain level on 0-100 mm visual analogue scales (VAS) at 2, 4, 6, 12, and 24 hours after the treatment. Recorded VAS scores and the number of pain-free patients (VAS<5) were compared between the two groups. A generalised linear estimation equation model, Chi-Square test, and Mann-Whitney U test were used to analyse the data.

resultsThe mean overall PEP score was statistically significantly lower in the DFK group than the IBU group with a p value of 0.030. Pain scores at 2 (p=0.034), 4 (p=0.021), and 24 hours (p=0.042) after the treatment were also significantly lower for DFK than IBU. The number of pain-free patients was also significantly higher in the DFK group at 2-hour (p=0.015) and 4-hour (p=0.048) time points and overall (p=0.013) compared to the IBU group. There was no adverse effect observed in either group.

conclusionBased on the results, taking multi-dose DFK 50 mg by the clock had better analgesic outcomes than multi-dose IBU 400 mg for PEP management. (EEJ-2022-01-07).

Indexed as

IbuprofenPulpitisAnalgesicsDiclofenacHumansMolarPostoperative PainProspective StudiesAnalgesicsDiclofenacIbuprofen

Identifiers

PMID37010198
PMCPMC10098432
OpenAlexW4292595419

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.