ArticlePlant physiology2023
Multi-copper oxidases SKU5 and SKS1 coordinate cell wall formation using apoplastic redox-based reactions in roots.
Article in Plant physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- GhNAC47 activates GhSKS6-mediated cell wall remodeling to promote cotton chemical defoliation.The New phytologist · 2026Article
- Transcriptomic analyses of piperitone inhibited sprouting of 'Yan 25' sweet potato storage roots.Food chemistry. Molecular sciences · 2026Article
- From structural complexity to circular applications: a comparative review of the enzymatic degradation of polydopamine, tannins, lignins, and melanins.RSC advances · 2026Review
- Genome-Wide Identification and Salt Tolerance Analysis of theInternational journal of molecular sciences · 2026Article
- Elucidation of the genetic basis underlying rooting ability in vegetatively propagated chrysanthemum.Horticulture research · 2026Article
- A systems biology framework integrating cross-species transcriptomics and PPI networks for Xylella fastidiosa resistance gene identification.BMC plant biology · 2025Article
- Genetic mapping and validation of QTL for whitefly resistance in cassava (Manihot esculenta Crantz).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Proteomics revealed novel functions and drought tolerance of Arabidopsis thaliana protein kinase ATG1.BMC biology · 2025Article
- The Rhizophagus irregularis permease RiFTR1 functions without a ferroxidase partner for reductive iron transport.Scientific reports · 2025Article
- Phosphate promotes Arabidopsis root skewing and circumnutation through reorganisation of the microtubule cytoskeleton.The New phytologist · 2024Article
- Systematic characterization of extracellular vesicles from potato (Frontiers in plant science · 2024Article
- Dual RNA-seq of maize andFrontiers in plant science · 2024Article
- Mapping Metal Accumulation Sites in Crop Fruits Revealed a Functional Iron Reservoir in the Tomato Seed Chalaza.Physiologia plantarumArticle
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary cell wall is a fundamental plant constituent that is flexible but sufficiently rigid to support the plant cell shape. Although many studies have demonstrated that reactive oxygen species (ROS) serve as important signaling messengers to modify the cell wall structure and affect cellular growth, the regulatory mechanism underlying the spatial-temporal regulation of ROS activity for cell wall maintenance remains largely unclear. Here, we demonstrate the role of the Arabidopsis (Arabidopsis thaliana) multicopper oxidase-like protein skewed 5 (SKU5) and its homolog SKU5-similar 1 (SKS1) in root cell wall formation through modulating ROS homeostasis. Loss of SKU5 and SKS1 function resulted in aberrant division planes, protruding cell walls, ectopic deposition of iron, and reduced nicotinamide adeninedinucleotide phosphate (NADPH) oxidase-dependent ROS overproduction in the root epidermis-cortex and cortex-endodermis junctions. A decrease in ROS level or inhibition of NADPH oxidase activity rescued the cell wall defects of sku5 sks1 double mutants. SKU5 and SKS1 proteins were activated by iron treatment, and iron over-accumulated in the walls between the root epidermis and cortex cell layers of sku5 sks1. The glycosylphosphatidylinositol-anchored motif was crucial for membrane association and functionality of SKU5 and SKS1. Overall, our results identified SKU5 and SKS1 as regulators of ROS at the cell surface for regulation of cell wall structure and root cell growth.
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