Evidence map›Paper›PMID 37009906›Full record

ArticleNMR in biomedicine2023

Neonatal hyperbilirubinemia differentially alters the neurochemical profiles of the developing cerebellum and hippocampus in a preterm Gunn rat model.

Katherine M Satrom, Raghavendra B Rao, Ivan Tkáč

Open access · hybridAbstract read
In one paragraph

Article in NMR in biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katherine M SatromDepartment of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0003-0893-3641
Raghavendra B RaoDepartment of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-6089-5972
Ivan TkáčCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0001-5054-0150
University of Minnesota · US

Funding

ResourceP40OD011062 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI Elizabeth C Bryda · 2012 to 2026
$24.0M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger · 2019 to 2026
$11.7M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Computer Aided Diagnostic System for Prostate Cancer Detection Using Quantitative Multiparametric MRIR01CA241159 · NCI · UNIVERSITY OF MINNESOTA · PI METZGER, GREGORY JOHN · 2021 to 2025
$3.0M
NCI NIH HHS R01 CA241159NIBIB NIH HHS P41 EB015894NIBIB NIH HHS P41 EB027061NIH HHS P40 OD011062NINDS NIH HHS P30 NS076408ODCDC CDC HHS P40 OD011062
6 · The paper itself

Abstract

Neonatal hyperbilirubinemia (NHB) can lead to brain injury in newborn infants by affecting specific regions including the cerebellum and hippocampus. Extremely preterm infants are more vulnerable to bilirubin neurotoxicity, but the mechanism and extent of injury is not well understood. A preterm version of the Gunn rat model was utilized to investigate severe preterm NHB. Homozygous/jaundiced Gunn rat pups were injected (i.p.) on postnatal day (P) 5 with sulfadimethoxine, which increases serum free bilirubin capable of crossing the blood-brain barrier and causing brain injury. The neurochemical profiles of the cerebellum and hippocampus were determined using in vivo

Indexed as

cerebellumGunn rathippocampushyperbilirubinemiaMRSneurochemical profilepreterm infant

Identifiers

PMID37009906
PMCPMC11809466
OpenAlexW4362506812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.