ArticleAnnals of human genetics2023
The impact of obesity on lung function measurements and respiratory disease: A Mendelian randomization study.
Article in Annals of human genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
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- Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.Current issues in molecular biology · 2026Review
- Body mass index and vital lung capacity as determinants of maximum oxygen volume (VO2 max): assessing fitness in a sedentary population.Physical activity and nutrition · 2026Article
- Association between relative fat mass and asthma risk in middle-aged and elderly Chinese population: a retrospective cohort study based on the CHARLS database.BMC public health · 2026Observational
- Transfer learning-based two-sample Mendelian randomization method for heterogeneous population.Briefings in bioinformatics · 2026Article
- Association between visceral lipid accumulation indicator and preserved ratio impaired spirometry in US adults: a population-based study from 2007 to 2012.Lipids in health and disease · 2025Article
- Causal relationship between Alzheimer's disease and cerebral small vessel disease: a Mendelian randomization study.Translational psychiatry · 2025Article
- Effects of High-Intensity Intermittent Training Combined withJournal of functional morphology and kinesiology · 2025Article
- Causal effect of life-course adiposity on the risk of respiratory diseases: a Mendelian randomization study.Nutrition & metabolism · 2025Article
- Association between clinical and pulmonary function features and diagnosis of cough variant asthma: a case-control study.BMJ open · 2025Observational
- Association Between Chronic Obstructive Pulmonary Disease and Low Muscle Mass in Korean Adults.Journal of clinical medicine · 2025Article
- Baseline Characteristics of Dupilumab-Treated Patients with Asthma in the Real World: The RAPID Global Registry.Advances in therapy · 2025Article
- Effect of Elevated Body Mass Index on Outcomes of Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis.Anatolian journal of cardiology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
introductionObservational studies have shown that body mass index (BMI) and waist-to-hip ratio (WHR) are both inversely associated with lung function, as assessed by forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). However, observational data are susceptible to confounding and reverse causation.
methodsWe selected genetic instruments based on their relevant large-scale genome-wide association studies. Summary statistics of lung function and asthma came from the UK Biobank and SpiroMeta Consortium meta-analysis (n = 400,102). After examining pleiotropy and removing outliers, we applied inverse-variance weighting to estimate the causal association of BMI and BMI-adjusted WHR (WHRadjBMI) with FVC, FEV1, FEV1/FVC, and asthma. Sensitivity analyses were performed using weighted median, MR-Egger, and MRlap methods.
resultsWe found that BMI was inversely associated with FVC (effect estimate, -0.167; 95% confidence interval (CI), -0.203 to -0.130) and FEV1 (effect estimate, -0.111; 95%CI, -0.149 to -0.074). Higher BMI was associated with higher FEV1/FVC (effect estimate, 0.079; 95%CI, 0.049 to 0.110) but was not significantly associated with asthma. WHRadjBMI was inversely associated with FVC (effect estimate, -0.132; 95%CI, -0.180 to -0.084) but has no significant association with FEV1. Higher WHR was associated with higher FEV1/FVC (effect estimate, 0.181; 95%CI, 0.130 to 0.232) and with increased risk of asthma (effect estimate, 0.027; 95%CI, 0.001 to 0.053).
conclusionWe found significant evidence that increased BMI is suggested to be causally related to decreased FVC and FEV1, and increased BMI-adjusted WHR could lead to lower FVC value and higher risk of asthma. Higher BMI and BMI-adjusted WHR were suggested to be causally associated with higher FEV1/FVC.
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