Evidence map›Paper›PMID 37009583›Full record

ArticleJournal of vitreoretinal diseases

Genetics and Age-Related Eye Disease Study Formulation Interaction in Neovascular Age-Related Macular Degeneration.

Stephen R Kaufman, Pradeepa Yoganathan, Kent W Small, Deepam Rusia, Sophia I Pachydaki, Stephen M Conti, Robert E Wenz, Mark A Gersman, Fadi S Shaya, Rafal Kustra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vitreoretinal diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Stephen R KaufmanVitreo-Retinal Consultants, Canton, OH, USA.
Pradeepa YoganathanKresge Eye Institute, Wayne State University, Detroit, MI, USA.ORCID https://orcid.org/0000-0002-4041-4297
Kent W SmallMacula and Retina Institute, Glendale, CA, USA.
Deepam RusiaVitreo-Retinal Consultants, Canton, OH, USA.
Sophia I PachydakiVitreo-Retinal Consultants, Canton, OH, USA.
Stephen M ContiVitreo-Retinal Consultants, Canton, OH, USA.
Robert E WenzVitreo-Retinal Consultants, Canton, OH, USA.
Mark A GersmanVitreo-Retinal Consultants, Canton, OH, USA.
Fadi S ShayaMacula and Retina Institute, Glendale, CA, USA.
Rafal KustraDana Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Macula and Retina Institute · USUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This work aims to determine whether previously defined genotype risk groups interact with Age-Related Eye Disease Study formulation (AREDS-F) use in progression to neovascular age-related macular degeneration (nvAMD). Methods: We conducted a case-only study of 265 nvAMD patients. Patients were anonymously genotyped at the complement factor H and age-related maculopathy susceptibility 2 loci and segregated into genotype groups (GTGs) defined by specific combinations of risk alleles. Physicians, who were blind to patients' GTGs, obtained patients' AREDS-F use history. The facility performing genetic analysis was blind to the AREDS-F use history. We used logistic analysis to estimate the interaction coefficient between AREDS-F use and GTG 2 vs GTG 3 in a general-population model. Results: The odds ratio of numbers of patients reporting prior AREDS-F use to nonuse for GTG 2 vs GTG 3 was 4.18 ( Conclusions: Our data indicate an interaction between GTGs and AREDS-F use that is consistent in size and direction with previously published reports, which had found that using AREDS-F supplements significantly increases the risk of nvAMD for some users and significantly protects other users.

Indexed as

complement factor Hdry AMD (nonneovascular)geneticswet AMD (neovascular)

Identifiers

PMID37009583
PMCPMC9976046
OpenAlexW3068863914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.