Evidence map›Paper›PMID 37009488›Full record

ArticleFrontiers in cell and developmental biology2023

Proteomic analysis defines the interactome of telomerase in the protozoan parasite,

Justin A Davis, Andres V Reyes, Nitika, Arpita Saha, Donald J Wolfgeher, Shou-Ling Xu, Andrew W Truman, Bibo Li, Kausik Chakrabarti

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Telomere maintenance in African trypanosomes.Frontiers in molecular biosciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Justin A DavisDepartment of Biological Sciences, University of North Carolina, Charlotte, NC, United States.
Andres V ReyesDepartment of Plant Biology and Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, CA, United States.
NitikaDepartment of Biological Sciences, University of North Carolina, Charlotte, NC, United States.
Arpita SahaCenter for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, College of Arts and Sciences, Cleveland State University, Cleveland, OH, United States.
Donald J WolfgeherDepartment of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, United States.
Shou-Ling XuDepartment of Plant Biology and Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, CA, United States.
Andrew W TrumanDepartment of Biological Sciences, University of North Carolina, Charlotte, NC, United States.
Bibo LiCenter for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, College of Arts and Sciences, Cleveland State University, Cleveland, OH, United States.
Kausik ChakrabartiDepartment of Biological Sciences, University of North Carolina, Charlotte, NC, United States.
University of North Carolina at Charlotte · USCarnegie Institution for Science · USCleveland State University · USUniversity of Chicago · US

Funding

Understanding the reciprocal regulation between Hsp70 and the DNA damage response.R01GM139885 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI TRUMAN, ANDREW WILLIAM · 2021 to 2024
$1.4M
Decoding RNA-Protein Interactions in Trypanosoma TelomeraseR15AI166764 · NIAID · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI CHAKRABARTI, KAUSIK · 2022 to 2023
$605k
NIAID NIH HHS R15 AI166764NIGMS NIH HHS R01 GM139885
6 · The paper itself

Abstract

Telomerase is a ribonucleoprotein enzyme responsible for maintaining the telomeric end of the chromosome. The telomerase enzyme requires two main components to function: the telomerase reverse transcriptase (TERT) and the telomerase RNA (TR), which provides the template for telomeric DNA synthesis. TR is a long non-coding RNA, which forms the basis of a large structural scaffold upon which many accessory proteins can bind and form the complete telomerase holoenzyme. These accessory protein interactions are required for telomerase activity and regulation inside cells. The interacting partners of TERT have been well studied in yeast, human, and

Indexed as

cell growthcell proliferationinteractomeparasiteribonucleoprotein (RNP)telomerasetelomereTrypanosoma brucei

Identifiers

PMID37009488
PMCPMC10061497
OpenAlexW4327597065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.