Evidence map›Paper›PMID 37009420›Full record

ArticleHepatic oncology2022

Management of hepatocellular carcinoma from diagnosis in routine clinical practice.

Tasneem Lokhandwala, Abdalla Aly, Eileen Farrelly, Joanne P Willey, Lois E Lamerato, Marcus Healey, Anna D Coutinho, Brian S Seal

Abstract read
In one paragraph

Article in Hepatic oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tasneem LokhandwalaXcenda LLC, Carrollton, TX 75010, USA.ORCID https://orcid.org/0000-0002-1983-9557
Abdalla AlyAstraZeneca PLC, Gaithersburg, MD 20878, USA.
Eileen FarrellyXcenda LLC, Carrollton, TX 75010, USA.
Joanne P WilleyXcenda LLC, Carrollton, TX 75010, USA.
Lois E LameratoHenry Ford Health System, Detroit, MI 48202, USA.
Marcus HealeyAstraZeneca PLC, Gaithersburg, MD 20878, USA.
Anna D CoutinhoXcenda LLC, Carrollton, TX 75010, USA.
Brian S SealAstraZeneca PLC, Gaithersburg, MD 20878, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To assess real-world management of patients diagnosed with hepatocellular carcinoma (HCC) within an integrated delivery network. Materials & methods: A retrospective cohort analysis of adults newly diagnosed with HCC from January 2014 to March 2019. Overall survival and treatment journey were assessed over the entire available follow-up period per patient. Results: Of the 462 patients, 85% had ≥1 treatment. The 24-month overall survival rate (95% CI) from first treatment was 77% (72-82%). Majority of Child-Pugh class A (71%) and B (60%) patients received locoregional therapy first. Half (53.6%) of the patients with liver transplantation first were Child-Pugh class C patients. Sorafenib was the predominant systemic therapy. Conclusion: This integrated delivery network data analysis offers a comprehensive insight into the real-world management of HCC.

Indexed as

Child-Pugh classhepatocellular carcinomaliver resection/excisionliver transplantationlocoregional therapiesoverall survivalradiofrequency ablationtransarterial chemoembolizationtransarterial radioembolizationtreatment journey

Identifiers

PMID37009420
PMCPMC10064261

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.