ReviewFrontiers in pediatrics2023
Nadir creatinine as a predictor of renal outcomes in PUVs: A systematic review and meta-analysis.
Review in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Creatinine as a predictor of proliferative diabetic retinopathy among patients with type 2 diabetes mellitus: a systematic review and meta-analysis.International urology and nephrology · 2025Pooled it
- Clinical characteristics and kidney outcomes in children with posterior urethral valve: a single-center experience.International urology and nephrology · 2026Article
- Prenatal Diagnosis of Posterior Urethral Valves: Timing of Diagnosis and Mid-Term Renal Function When Second and Third Trimester Ultrasounds Are Systematically Performed.Prenatal diagnosis · 2026Article
- Delayed Diagnosis of Posterior Urethral Valves in a 14-Year-Old Adolescent.Reports (MDPI) · 2026Article
- Prognostic evaluation of boys with posterior urethral valves using a recursive feature elimination machine learning framework.Frontiers in pediatrics · 2026Article
- Development and international validation of a novel multivariate prognostic tool: posterior urethral valve risk of chronic kidney disease (PURK) score.Pediatric nephrology (Berlin, Germany) · 2025Article
- Management of patients with posterior urethral valves "from the fetus to adolescence": French national diagnostic and care protocol (NDCP).Orphanet journal of rare diseases · 2025Article
- Care of children with posterior urethral valves after initial endoscopic incision/ablation: what a nephrologist needs to know.Pediatric nephrology (Berlin, Germany) · 2025Review
- Does unilateral reflux have a protective effect in posterior urethral valve patients?Pediatric surgery international · 2025Article
- Review
- Beyond Childhood: The Lifelong Kidney Risks for Children with Posterior Urethral Valves.Journal of the American Society of Nephrology : JASN · 2024Article
- Long-Term Kidney Outcomes in Children with Posterior Urethral Valves: A Population-Based Cohort Study.Journal of the American Society of Nephrology : JASN · 2024Article
- Nadir Creatinine in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): A Single-Center Experience.Children (Basel, Switzerland) · 2024Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Posterior urethral valves (PUVs) represent the most severe pediatric obstructive uropathy, responsible for chronic renal failure in up to 65% of cases and progression to end-stage kidney disease (ESKD) in about 8%-21% of patients. Unfortunately, renal outcomes have poorly improved over time. The key point is to identify patients at risk; thus, several prenatal and postnatal prognostic factors have been analyzed to improve clinical outcomes. Postnatal nadir creatinine seems to accurately predict long-term renal prognosis, but there is no definitive evidence to support this finding. Objective: We performed a systematic review with meta-analysis to analyze the predictive value of nadir creatinine on long-term renal function in infants with PUVs. Methods: We conducted this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed and Cochrane Library were systematically searched for studies published from January 2008 to June 2022. All the articles were checked independently by two reviewers in two steps. Results: A total of 24 articles were screened, and 13 were included for data extraction. Data from 1,731 patients with PUVs were analyzed, with a mean follow-up of 5.5 years; of these, on average, 37.9% developed chronic kidney disease (CKD) and 13.6% developed ESKD. All the articles evaluated nadir creatinine as a predictor of CKD, most using a level of 1 mg/dL, with statistical significance at the 5% level. The relative risk of developing CKD in patients with creatinine values higher than the nadir cutoff considered was 7.69 (95% CI: 2.35-25.17, Conclusions: Nadir creatinine is the best prognostic factor for long-term renal function in patients affected by PUV. A value above the cutoff of 1 mg/dL should be considered a significant predictor for the risk of CKD and ESKD. Further studies are needed to define different nadir creatinine cutoffs for better stratification of the different CKD stages and for the development of reliable scores, which include the association of several variables.
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