Evidence map›Paper›PMID 37009247›Full record

ArticleHeliyon2023

Quivering hand and heart: Parkinson's disease is not associated with increased in-hospital mortality in atrial fibrillation hospitalizations: A nationwide analysis.

Emmanuel Ukenenye, Tolulope Oshiba, Emeka Okoronkwo, Elvis Obomanu, Gideon Asaolu, Alexsandra Urhi, Iyanu Victoria Olateju, Henry Onyemarim, Consolata Uzzi, Gabriel Alugba and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Emmanuel UkenenyeOne Brooklyn Health-Brookdale University Hospital and Medical Center Medical, Brooklyn, NY, United States.
Tolulope OshibaHospitalist/Emergency Medicine Department, University of Texas Health Science Center/UT Physicians/Memorial Hermann Hospital, 6410 Fannin St, Houston, TX 77030, United States.
Emeka OkoronkwoNeurology Unit of Department of Medicine, Lagos University Teaching Hospital, Ishaga Rd, Idi-Araba, Lagos 102215, Nigeria.
Elvis ObomanuDepartment of Project Management, Translational Research in Oncology, 9925 109 St NW Suite 1100, Edmonton, AB T5K 2J8, Alberta, Canada.
Gideon AsaoluMandeville Regional Hospital, Mandeville, Manchester, Jamaica.
Alexsandra UrhiFederal Neuropsychiatric Hospital, New Lagos Rd, Uselu 300103, Benin City, Edo, Nigeria.
Iyanu Victoria OlatejuDepartment of Internal Medicine, Medstar Union Memorial Hospital, 201 E University Pkwy, Baltimore, MD 21218, United States.
Henry OnyemarimAsaba Specialist Hospital, GRA Phase 1 320108, Asaba, Delta State, Nigeria.
Consolata UzziColumbus Specialty Hospital, 495 N 13th St, Newark, NJ 07107, United States.
Gabriel AlugbaDelta State University, Abraka - Abbi Rd, 330105, Uruoka, Nigeria.
Adeolu Funso OladunjoyeClinical Menninger Department of Psychiatry, Baylor College of Medicine, Houston TX 77030, United States.
Olubunmi OladunjoyeSection of General Internal Medicine, Baylor College of Medicine, 7200 Cambridge St, Houston, TX 77030, United States.
Baylor College of Medicine · USDelta State University · NGFederal Neuro Psychiatric Hospital · NGLagos University Teaching Hospital · NGMedStar Union Memorial Hospital · USMemorial Hermann · USNorthern Caribbean University · JMTranslational Research in Oncology · CAUniversity of the West Indies System · JM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Autonomic dysfunction in Parkinson's disease (PD) includes cardiovascular dysregulations which may manifest as an increased risk of atrial fibrillation (AF). However, data on the impact of PD in AF patients is lacking. Our study aimed to investigate the differences in in-hospital mortality of patients admitted for AF with underlying PD versus those without PD. Methods: We examined the National Inpatient Sample (NIS) database from 2016 to 2019 for hospitalizations of AF as a principal diagnosis with and without PD as a secondary diagnosis. The primary outcome was inpatient mortality. The secondary endpoints were ventricular tachycardia (VT), ventricular fibrillation (VF), acute heart failure (AHF), cardiogenic shock (CS), cardiac arrest (CA), total hospital charge (THC), and length of stay (LOS). Results: Of 1,861,859 A F hospitalizations, 0.01% (19,490) had coexisting PD. Cohorts of PD vs No-PD had a mean age of 78.1 years [CI 77.9-78.4] vs 70.5 years [CI 70.4-70.5]; male (56.3% vs 50.7%), female (43.7% vs 49.3%). The PD category had similar in-hospital mortality with the no-PD category (OR Conclusion: Co-existing PD in patients admitted for AF was not associated with increased in-hospital mortality; however, there were lower odds of AHF and VT. The diminished arrhythmogenic neurohormonal axis may explain these cardiovascular benefits. Notwithstanding, to better understand the outcomes of AF in patients with PD, additional studies are required.

Indexed as

Acute heart failureAtrial fibrillationIn-hospital mortalityParkinson's diseaseVentricular tachycardia

Identifiers

PMID37009247
PMCPMC10060677
OpenAlexW4328104186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.