Volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l-alanine and l-glutamine in aqueous solutions.

Nur Farahani Zolkiflee, Meor Mohd Redzuan Meor Mohd Affandi, Abu Bakar Abdul Majeed

Open access · goldAbstract read

In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

1.3field-weighted citation impact, top 24% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nur Farahani ZolkifleeLaboratory Fundamental of Pharmaceutics, Universiti Teknologi MARA (UiTM) Selangor, 42300, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.

Meor Mohd Redzuan Meor Mohd AffandiLaboratory Fundamental of Pharmaceutics, Universiti Teknologi MARA (UiTM) Selangor, 42300, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.

Abu Bakar Abdul MajeedBrain Research Laboratory, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Selangor, 42300, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.

Universiti Teknologi MARA · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levocetirizine dihydrochloride (LCTZ) is a second-generation antihistamine known for its efficacy without sedation. However, the binding mechanism with plasma protein which makes it devoid of sedative effects is yet to be uncovered. In this study, we elucidated thermodynamic parameters of solute-solvent and solute-cosolute interactions between LCTZ, and the amino acids l-alanine (Ala) and l-glutamine (Gln) in aqueous solutions. The volumetric and conductance parameters were calculated using the experimental density and conductance data of aqueous solutions of Ala and Gln (concentration range of 0.02-0.20 mol kg

Indexed as

Conductometric studyDrug-amino acid interactionsPhysicochemicalSolute-solute interactionsSolute-solvent interactionsThermodynamicsVolumetric study

Identifiers

PMID37009243

DOI10.1016/j.heliyon.2023.e14363

PMCPMC10060571

OpenAlexW4323304912

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.