Evidence map›Paper›PMID 37009062›Full record

ArticleExpert review of ophthalmology2023

Factors affecting the prevalence, severity, and characteristics of ocular surface pain.

Victor Sanchez, Noah K Cohen, Elizabeth Felix, Anat Galor

Open access · greenAbstract read
In one paragraph

Article in Expert review of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. The Problem With Dry Eye Trials.JAMA ophthalmology · 2024
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Victor SanchezDepartment of Ophthalmology, New York University School of Medicine, 550 First Avenue, New York, NY 10016.
Noah K CohenBascom Palmer Eye Institute, University of Miami, 900 NW 17th Street, Miami, FL 33136.
Elizabeth FelixBascom Palmer Eye Institute, University of Miami, 900 NW 17th Street, Miami, FL 33136.
Anat GalorBascom Palmer Eye Institute, University of Miami, 900 NW 17th Street, Miami, FL 33136.
United States Department of Veterans Affairs · USNew York University · USUniversity of Miami · US

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Differentiation of Clinical Phenotypes of Inflammatory and Neuropathic Ocular Pain Conditions with Morphologic Measures and Functional Brain ImagingU01EY034686 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Eric Alan Moulton · 2022 to 2026
$4.7M
Tear protein biomarkers of refractive surgery painR61EY032468 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A, GALOR, ANAT · 2020 to 2022
$2.0M
Dry Eye and MicroenvironmentR01EY026174 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALOR, ANAT, KUMAR, NARESH · 2016 to 2020
$1.9M
Neural mechanisms underlying photophobia and dry eyeI01CX002015 · VA · MIAMI VA HEALTH CARE SYSTEM · PI Anat Galor · 2020 to 2026
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A pilot study of the safety and feasibility of transcutaneous electrical nerve stimulation (TENS) for chronic ocular painI21RX003883 · VA · MIAMI VA HEALTH CARE SYSTEM · PI FELIX, ELIZABETH ROY · 2022 to 2023
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Lipid mediators and their signaling in ocular surface inflammation and meibomian gland dysfunctionI01BX004893 · VA · MIAMI VA HEALTH CARE SYSTEM · PI GALOR, ANAT, MANDAL, NAWAJES · 2021 to 2025
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BLRD VA I01 BX004893CSRD VA I01 CX002015NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY026174NEI NIH HHS R61 EY032468NEI NIH HHS U01 EY034686RRD VA I21 RX003883
6 · The paper itself

Abstract

Introduction: Ocular surface pain has been traditionally lumped under the umbrella term "dry eye" (DE) but is now understood as its own entity and can occur in the absence or presence of tear dysfunction. Identifying patients at risk for the development of chronic ocular surface pain, and factors contributing to its severity are important in providing precision medicine to patients. Areas covered: In this review, we discuss factors linked to the presence and severity of ocular surface pain, including eye related features, systemic characteristics, and environmental findings. We discuss corneal nerves, whose anatomic and functional integrity can be characterized through Expert opinion: Intrinsic and extrinsic factors contribute to ocular surface pain and must be considered when evaluating an individual patient. These factors can inform the suspected etiology of the pain, and guide management decisions such as tear replacement or medications targeting nerve pain.

Indexed as

dry eyehyperalgesianerve sensitizationneuropathic painnociceptive painocular surface painpain

Identifiers

PMID37009062
PMCPMC10062703
OpenAlexW4312013568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.