Evidence map›Paper›PMID 37009020›Full record

ArticleERJ open research2023

Cardiovascular disease-linked plasma proteins are mainly associated with lung volume.

Andreas Rydell, Elisabet Nerpin, XingWu Zhou, Lars Lind, Eva Lindberg, Jenny Theorell Haglöw, Tove Fall, Christer Janson, Karin Lisspers, Sölve Elmståhl and 5 more

Open access · goldAbstract read
In one paragraph

Article in ERJ open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Systemic inflammatory biomarkers in relation to lung function and exercise-induced bronchoconstriction in adolescents.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Andreas RydellDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institute, Huddinge, Sweden.
Elisabet NerpinDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0003-3880-2132
XingWu ZhouDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Eva LindbergDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Jenny Theorell HaglöwDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0003-2819-2799
Tove FallDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Christer JansonDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Karin LisspersDepartment of Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden.
Sölve ElmståhlDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Suneela ZaighamDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-9132-5665
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Peter M NilssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Johan ÄrnlövDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institute, Huddinge, Sweden.
Andrei MalinovschiDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-4098-7765
Uppsala University · SEDalarna University · SELund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV Methods: We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV Results: Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV Conclusions: Five proteins were associated with both FEV

Identifiers

PMID37009020
PMCPMC10052712
OpenAlexW4318070696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.