Evidence map›Paper›PMID 37008944›Full record

ArticleFrontiers in endocrinology2023

The length of FOXE1 polyalanine tract in congenital hypothyroidism: Evidence for a pathogenic role from familial, molecular and cohort studies.

Elisa Stellaria Grassi, Giuditta Rurale, Tiziana de Filippis, Davide Gentilini, Erika Carbone, Francesca Coscia, Sarah Uraghi, Martyn Bullock, Roderick J Clifton-Bligh, Abhinav K Gupta and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Identification of GermlineInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Elisa Stellaria GrassiDepartment of Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Giuditta RuraleLaboratory of Endocrine and Metabolic Research, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Auxologico Italiano, Milan, Italy.
Tiziana de FilippisLaboratory of Endocrine and Metabolic Research, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Auxologico Italiano, Milan, Italy.
Davide GentiliniDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Erika CarboneLaboratory of Endocrine and Metabolic Research, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Auxologico Italiano, Milan, Italy.
Francesca CosciaStructural Biology Centre, Human Technopole, Milano, Italy.
Sarah UraghiDepartment of Health Science, University of Milan, Milan, Italy.
Martyn BullockCancer Genetics Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Roderick J Clifton-BlighCancer Genetics Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Abhinav K GuptaDepartment of Diabetes and Endocrine Sciences, CK Birla Hospitals, Jaipur, Rajasthan, India.
Luca PersaniDepartment of Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITIRCCS Istituto Auxologico Italiano · ITUniversity of Milan · ITUniversity of Sydney · AUHuman Technopole · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: We applied NGS screening to a large CH family and a cohort of 1752 individuals and validated these results by Results: A new heterozygous Discussion: We provide new evidence that disentangle the pathophysiological role of FOXE1 polyalanine tract, thereby significantly broadening the perspective on the role of

Indexed as

Congenital HypothyroidismForkhead Transcription FactorsHumansPeptidesTranscription FactorsForkhead Transcription FactorsFOXE1 protein, humanPeptidespolyalanineTranscription Factorsathyreosiscongenital hypothyroidismforkhead transcription factorFOXE1next generation sequencingpolyalanine tracts

Identifiers

PMID37008944
PMCPMC10060985
OpenAlexW4327605568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.