Evidence map›Paper›PMID 37008938›Full record

Observational studyFrontiers in endocrinology2023

Investigating the association between fasting insulin, erythrocytosis and HbA1c through Mendelian randomization and observational analyses.

Anthony Nguyen, Rana Khafagy, Habiba Hashemy, Kevin H M Kuo, Delnaz Roshandel, Andrew D Paterson, Satya Dash

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Anthony NguyenDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
Rana KhafagyDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
Habiba HashemyDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
Kevin H M KuoDivision of Medical Oncology and Haematology, Department of Medicine, University Health Network, Toronto, ON, Canada.
Delnaz RoshandelGenetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Andrew D PatersonGenetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Satya DashDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
University of Toronto · CAHospital for Sick Children · CAUniversity Health Network · CA

Funding

Cancer Research UK 175041
6 · The paper itself

Abstract

Background: Insulin resistance (IR) with associated compensatory hyperinsulinemia (HI) are early abnormalities in the etiology of prediabetes (preT2D) and type 2 diabetes (T2D). IR and HI also associate with increased erythrocytosis. Hemoglobin A1c (HbA1c) is commonly used to diagnose and monitor preT2D and T2D, but can be influenced by erythrocytosis independent of glycemia. Methods: We undertook bidirectional Mendelian randomization (MR) in individuals of European ancestry to investigate potential causal associations between increased fasting insulin adjusted for BMI (FI), erythrocytosis and its non-glycemic impact on HbA1c. We investigated the association between the triglyceride-glucose index (TGI), a surrogate measure of IR and HI, and glycation gap (difference between measured HbA1c and predicted HbA1c derived from linear regression of fasting glucose) in people with normoglycemia and preT2D. Results: Inverse variance weighted MR (IVWMR) suggested that increased FI increases hemoglobin (Hb, b=0.54 ± 0.09, p=2.7 x 10 Conclusions: MR suggests increased FI increases erythrocytosis and might potentially decrease HbA1c by non-glycemic effects. Increased TGI, a surrogate measure of increased FI, associates with lower-than-expected HbA1c in people with preT2D. These findings merit confirmatory studies to evaluate their clinical significance.

Indexed as

Carcinoma, Renal CellDiabetes Mellitus, Type 2HyperinsulinismInsulin ResistanceKidney NeoplasmsPolycythemiaBlood GlucoseFastingGlucoseGlycated HemoglobinHumansInsulinMendelian Randomization AnalysisBlood GlucoseGlucoseGlycated HemoglobinInsulinerythrocytosishemoglobin A1chyperinsulinemiainsulin resistancetype 2 diabetes (T2D)

Identifiers

PMID37008938
PMCPMC10064082
OpenAlexW4327731996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.