Evidence map›Paper›PMID 37008654›Full record

ArticleIEEE access : practical innovations, open solutions2023

Assessing Inter-Annotator Agreement for Medical Image Segmentation.

Feng Yang, Ghada Zamzmi, Sandeep Angara, Sivaramakrishnan Rajaraman, André Aquilina, Zhiyun Xue, Stefan Jaeger, Emmanouil Papagiannakis, Sameer K Antani

Abstract read
In one paragraph

Article in IEEE access : practical innovations, open solutions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Benchmarking variability in semantic segmentation in minimally invasive abdominal surgery.International journal of computer assisted radiology and surgery · 2026
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  8. Semi-automated end-to-end quality control system for annotation data based on automated Cobb angle measurement.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Feng YangNational Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-8334-7450
Ghada ZamzmiNational Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-4723-5539
Sandeep AngaraNational Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Sivaramakrishnan RajaramanNational Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-0871-8634
André AquilinaDYSIS Medical Ltd., EH12 9DQ Edinburgh, U.K.
Zhiyun XueNational Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-0644-385X
Stefan JaegerNational Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0001-6877-4318
Emmanouil PapagiannakisDYSIS Medical Ltd., EH12 9DQ Edinburgh, U.K.ORCID 0000-0001-8867-9203
Sameer K AntaniNational Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-0040-1387

Funding

Applied Clinical InformaticsZIHLM010016 · NLM · NATIONAL LIBRARY OF MEDICINE · PI LYNCH, PAUL · 2021 to 2025
$36.5M
Machine learning and artificial intelligence research for clinical medical image processingZIALM010018 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ANTANI, SAMEER · 2021 to 2025
$9.0M
Intramural NIH HHS Z99 LM999999
6 · The paper itself

Abstract

Artificial Intelligence (AI)-based medical computer vision algorithm training and evaluations depend on annotations and labeling. However, variability between expert annotators introduces noise in training data that can adversely impact the performance of AI algorithms. This study aims to assess, illustrate and interpret the inter-annotator agreement among multiple expert annotators when segmenting the same lesion(s)/abnormalities on medical images. We propose the use of three metrics for the qualitative and quantitative assessment of inter-annotator agreement: 1) use of a common agreement heatmap and a ranking agreement heatmap; 2) use of the extended Cohen's kappa and Fleiss' kappa coefficients for a quantitative evaluation and interpretation of inter-annotator reliability; and 3) use of the Simultaneous Truth and Performance Level Estimation (STAPLE) algorithm, as a parallel step, to generate ground truth for training AI models and compute Intersection over Union (IoU), sensitivity, and specificity to assess the inter-annotator reliability and variability. Experiments are performed on two datasets, namely cervical colposcopy images from 30 patients and chest X-ray images from 336 tuberculosis (TB) patients, to demonstrate the consistency of inter-annotator reliability assessment and the importance of combining different metrics to avoid bias assessment.

Indexed as

agreementCohen’s kappaFleiss’ kappaheatmapinter-annotatorReliabilitySTAPLE

Identifiers

PMID37008654
PMCPMC10062409

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.