Evidence map›Paper›PMID 37008569›Full record

ArticleOpen forum infectious diseases2023

Hyponatremia as a Predictor of Cryptococcal Meningitis and Death Among Asymptomatic Persons With HIV and Cryptococcal Antigenemia.

Alice Lehman, Elizabeth Nalintya, Abduljewad Wele, Paul Kirumira, Rose Naluyima, Teopista Namuli, Fred Turya Musa, Caleb P Skipper, David B Meya, David R Boulware and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Alice LehmanDivision of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-4690-784X
Elizabeth NalintyaInfectious Disease Institute, Makerere University, Kampala, Uganda.
Abduljewad WeleDivision of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Paul KirumiraInfectious Disease Institute, Makerere University, Kampala, Uganda.
Rose NaluyimaInfectious Disease Institute, Makerere University, Kampala, Uganda.
Teopista NamuliInfectious Disease Institute, Makerere University, Kampala, Uganda.
Fred Turya MusaInfectious Disease Institute, Makerere University, Kampala, Uganda.
Caleb P SkipperDivision of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-0000-8876
David B MeyaInfectious Disease Institute, Makerere University, Kampala, Uganda.
David R BoulwareDivision of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-4715-0060
Radha RajasinghamDivision of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-5531-0231
Makerere University · UGUniversity of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Institutional Career Development CoreKL2TR002492 · NCATS · UNIVERSITY OF MINNESOTA · PI INGBAR, DAVID H · 2018 to 2022
$6.3M
Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026
$6.1M
Operational Research for Cryptococcal Antigen Screening (ORCAS) of HIV PatientsU01AI125003 · NIAID · UNIVERSITY OF MINNESOTA · PI BOULWARE, DAVID R, MEYA, DAVID BISAGAYA · 2016 to 2020
$3.4M
Enhanced Antifungal Therapy to Improve Survival in Early Disseminated Cryptococcal InfectionU01AI174978 · NIAID · UNIVERSITY OF MINNESOTA · PI Radha Rajasingham · 2023 to 2026
$2.6M
Evaluation of CRAG screening with enhanced antifungal therapy for asymptomatic CRAG-positive personsK23AI138851 · NIAID · UNIVERSITY OF MINNESOTA · PI RAJASINGHAM, RADHA · 2018 to 2022
$954k
NCATS NIH HHS KL2 TR002492NCATS NIH HHS UL1 TR002494NIAID NIH HHS K23 AI138851NIAID NIH HHS T32 AI055433NIAID NIH HHS U01 AI125003NIAID NIH HHS U01 AI174978
6 · The paper itself

Abstract

Among persons with human immunodeficiency virus-associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia.

Indexed as

cryptococcal meningitisHIVhyponatremia

Identifiers

PMID37008569
PMCPMC10061560
OpenAlexW4361205571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.